88334-76-3Relevant academic research and scientific papers
INHIBITION OF OLIG2 ACTIVITY
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Paragraph 00358-00359, (2018/03/25)
Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of Olig2. Also described herein are methods of using such Olig2 inhibitors, alone and in combination with other compounds, for treating cancer and other diseases. In particular the Olig2 inhibitors may be used to treat glioblastoma.
1,2,5-oxadiazoles as inhibitors of indoleamine 2,3-dioxygenase
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Page/Page column 50; 72, (2016/05/24)
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
1,2,5-OXADIAZOLES AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
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, (2010/02/17)
The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives.
HETEROCYCLIC COMPOUND
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Page/Page column 46-47, (2010/12/30)
The present invention provides to a compound having melanin-concentrating hormone receptor antagonistic action and low toxicity, and useful as a agent for the prophylaxis or treatment of obesity and the like. The present invention relates to a compound re
INHIBITORS OF DIPEPTIDYL PEPTIDASE IV
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Page/Page column 84, (2010/02/11)
The invention relates to compounds of the formula (I) or pharmaceutically-acceptable salts thereof wherein Ar, R 1 , R2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 have any of the meanings defined in the description, which possess dipeptidyl peptidase IV (DPP-IV) inhibitory activity and accordingly have value in the treatment of disease states associated with DPP-IV activity, such as diabetes mellitus. Processes for the preparation of said compounds, intermediates in said processes, pharmaceutical compositions containing said compounds or salts, and the use of said compounds or salts are also described.
