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Usage

Uses

Used in Pharmaceutical Industry:
1-(2-fluorobenzyl)piperidin-3-amine(SALTDATA: 2HCl) is used as a potential active pharmaceutical ingredient for its effects on the central nervous system, given the presence of the piperidin-3-amine group. Its application in this industry is due to the historical use of piperidines in neurological and psychiatric medications.
Used in Drug Formulation:
1-(2-fluorobenzyl)piperidin-3-amine(SALTDATA: 2HCl) is used as a solubility and stability enhancer in drug formulations, thanks to its salt form with two chloride ions. This characteristic can improve the compound's pharmaceutical properties, making it more suitable for various drug delivery methods.
Used in Chemical Research:
1-(2-fluorobenzyl)piperidin-3-amine(SALTDATA: 2HCl) is also used as a subject of chemical research to explore its unique properties and potential interactions with biological targets, which could lead to the development of new therapeutic agents.

Upstream product

• 345-35-7 2-fluorobenzyl chloride 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation

The complexity of Alzheimer's disease (AD) calls for search of multifunctional compounds as potential candidates for effective therapy. A series of phthalimide and saccharin derivatives linked by different alicyclic fragments (piperazine, hexahydropyrimidine, 3-aminopyrrolidine or 3-aminopiperidine) with phenylalkyl moieties attached have been designed, synthesized, and evaluated as multifunctional anti-AD agents with cholinesterase, β-secretase and β-amyloid inhibitory activities. In?vitro studies showed that the majority of saccharin derivatives with piperazine moiety and one phthalimide derivative with 3-aminopiperidine fragment exhibited inhibitory potency toward acetylcholinesterase (AChE) with EeAChE IC50values ranging from 0.83?μM to 19.18?μM. The target compounds displayed inhibition of human β-secretase-1 (hBACE1) ranging from 26.71% to 61.42% at 50?μM concentration. Among these compounds, two multifunctional agents (26, [2-(2-(4-benzylpiperazin-1-yl)ethyl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide] and 52, 2-(2-(3-(3,5-difluorobenzylamino)piperidin-1-yl)ethyl)isoindoline-1,3-dione) have been identified. Compound 26 exhibited the highest inhibitory potency against EeAChE (IC50?=?0.83?μM) and inhibitory activity against hBACE1 (33.61% at 50?μM). Compound 52 is a selective AChE inhibitor (IC50 AChE?=?6.47?μM) with BACE1 inhibitory activity (26.3% at 50?μM) and it displays the most significant Aβ anti-aggregating properties among all the obtained compounds (39% at 10?μM). Kinetic and molecular modeling studies indicate that 26 may act as non-competitive AChE inhibitor able to interact with both catalytic and peripheral active site of the enzyme.