883531-28-0

Basic information

• Product Name: 2-Fluoro-4-methoxyphenylacetic acid
• Synonyms: 4-(Carboxymethyl)-3-fluoroanisole;2-fluoro-4-methoxylphenylacetic acid;2-(2-fluoro-4-methoxyphenyl)acetic acid;2-Fluoro-4-Methoxy acid;2-Fluoro-4-Methoxyphenylacetic acid, JRD, 97%
• CAS NO: 883531-28-0
• Molecular Formula: C₉H₉FO₃
• Molecular Weight: 184.17
• EINECS: 200-258-5
• Product Categories: Fluorine series
• Mol File: 883531-28-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 290.6 °C at 760 mmHg
• Flash Point: 129.5 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.000943mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.17±0.10(Predicted)
• CAS DataBase Reference: 2-Fluoro-4-methoxyphenylacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-methoxyphenylacetic acid(883531-28-0)
• EPA Substance Registry System: 2-Fluoro-4-methoxyphenylacetic acid(883531-28-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 883531-28-0(Hazardous Substances Data)

Usage

General Description

2-Fluoro-4-methoxyphenylacetic acid is a chemical compound with the molecular formula C9H9FO3. It is a white crystalline solid with a molecular weight of 182.16 g/mol. 2-Fluoro-4-methoxyphenylacetic acid is a derivative of phenylacetic acid, with a fluoro group and a methoxy group attached to the phenyl ring. It is commonly used as a building block in organic synthesis and pharmaceutical research. It has potential applications in the development of new drugs and pharmaceutical products. The compound's properties and reactivity make it a valuable tool in the study of organic chemistry and drug discovery.

InChI:InChI=1/C9H9FO3/c1-13-7-3-2-6(4-9(11)12)8(10)5-7/h2-3,5H,4H2,1H3,(H,11,12)

Upstream product

• 1403674-64-5 2,2,2-trichloro-1-(2-fluoro-4-methoxyphenyl)ethanol 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 

Downstream Products

• 1403674-65-6 2-(2-fluoro-4-methoxyphenyl)acetic acid chloride 
• 1403674-94-1 C₂₅H₂₂FNO₃ 
• 1181692-22-7 (R)-1-(6-(3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl)-3,4-dihydroisoquinolin-2(1H)-yl)ethanone trifluoroacetate 
• 1147392-15-1 (R)-3-fluoro-4-(2-(2-methylpyrrolidin-1-yl)ethyl)phenyl trifluoromethanesulfonate 
• 1147392-09-3 (R)-1-(2-fluoro-4-methoxyphenethyl)-2-methylpyrrolidine 
• 68886-07-7 (2-fluoro-4-hydroxylphenyl)acetic acid 
• 1147392-04-8 2-(2-fluoro-4-methoxyphenyl)ethanol 

Relevant articles and documents

Influence of chlorine or fluorine substitution on the estrogenic properties of 1-alkyl-2,3,5-tris(4-hydroxyphenyl)-1H-pyrroles

In continuation of our previous work, several 1-alkyl-2,3,5-tris(4- hydroxyphenyl)aryl-1H-pyrroles with chlorine or fluorine substituents in the aryl residues were synthesized and tested for estrogen receptor (ER) binding at isolated ERα/ERβ receptors (HAP assay) and in transactivation assays using ERα-positive MCF-7/2a as well as U2-OS/ERα and U2-OS/ERβ cells. In the competition experiment at ERα the compounds displayed very high relative binding affinities of up to 37% (determined for 8m) but with restricted subtype selectivity (e.g., ERα/ERβ (8m) = 9). The highest estrogenic potency in ERα-positive MCF-7/2a cells was determined for 2,3,5-tris(2-fluoro-4-hydroxyphenyl)-1-propyl-1H-pyrrole 8m (EC50 = 23 nM), while in U2-OS/ERα cells 2-(2-fluoro-4-hydroxyphenyl)-3,5-bis(4- hydroxyphenyl)-1-propyl-1H-pyrrole 8b (EC50 = 0.12 nM) was the most potent agonist, only 30-fold less active than estradiol (E2, EC50 = 0.004 nM). In U2-OS/ERβ cells for all pyrroles no transactivation could be observed, which indicates that they are selective ERα agonists in cellular systems.