883539-49-9

Usage

Uses

Used in Medicinal Chemistry:
(1-Ethyl-1H-indol-3-ylsulfanyl)-acetic acid is used as a potential drug candidate in medicinal chemistry for its indole moiety, which may be important for targeting various biological processes. The presence of a sulfanyl and acetic acid group may also impart specific chemical properties or biological activities to the compound, making it useful for pharmaceutical research and drug discovery efforts.

InChI:InChI=1/C12H13NO2S/c1-2-13-7-11(16-8-12(14)15)9-5-3-4-6-10(9)13/h3-7H,2,8H2,1H3,(H,14,15)

Upstream product

• 1052405-94-3 C₁₁H₁₃N₃S*HI 
• 79-11-8 chloroacetic acid 
• 10604-59-8 N-Ethylindole 
• 120-72-9 indole 

Relevant academic research and scientific papers

Directed synthesis and immunoactive properties of (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)alkanecarboxylic acids

A general method for the synthesis of 1-alkyl(allyl)(benzyl)-substituted (indol-3-yl)-sulfanylalkanecarboxylic acids and hexane-1,6-diyl(1,4- phenylenemethylene)bisindol-3-ylsulfanylalkanecarboxylic acids from the corresponding N-substituted indoles and bisindoles, thiourea, iodine, and halogencarboxylic acids was developed. The oxidation of substituted (indol-3-yl)sulfanylalkanecarboxylic acids for the first time afforded their analogs containing the sulfonyl group. New (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanyl(sulfonyl)-alkanecarboxylic acids, which are structural analogs of highly active immunomodulators of indacetamin and VILIM, were synthesized. Among the studied (2-hydroxyethyl)ammonium salts of 1-R-indol-3-ylsulfanylacetic and -sulfonylalkanecarboxylic acids, the compounds exhibiting high dose-dependent antiproliferative activity by the ability to affect the spontaneous and mitogen-stimulated splenocyte proliferation of mice in vitro were found.