883541-16-0

Basic information

• Product Name: 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE
• Synonyms: 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE
• CAS NO: 883541-16-0
• Molecular Formula: C₁₂H₁₀FNO
• Molecular Weight: 203.21
• Mol File: 883541-16-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE(883541-16-0)
• EPA Substance Registry System: 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE(883541-16-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 883541-16-0(Hazardous Substances Data)

Usage

Description

1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE is a chemical compound characterized by its molecular formula C12H10FNO. It is an aldehyde derivative of pyrrole, featuring a 4-fluoro-benzyl group that imparts unique reactivity to the molecule. 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE is widely utilized in organic synthesis and medicinal chemistry for the creation of pharmaceutical compounds and biologically active molecules.

Uses

Used in Pharmaceutical Industry:
1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity allow for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, 1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE serves as a valuable building block for the construction of complex organic compounds. The 4-fluoro-benzyl group can be employed for the modification of other molecules in chemical reactions, enabling the creation of a diverse range of chemical products.
Used in Medicinal Chemistry:
1-(4-FLUORO-BENZYL)-1H-PYRROLE-2-CARBALDEHYDE is also utilized in medicinal chemistry for the preparation of biologically active molecules. Its incorporation into these molecules can lead to the development of novel therapeutic agents with improved efficacy and selectivity.

Upstream product

• 1003-29-8 2-pyrrole aldehyde 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 1369355-91-8 F_.6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid ethyl ester 
• 868616-78-8 6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2-hydroxy-4-oxo-2,5-hexdienoic acid 

Relevant articles and documents

Design, synthesis and biological evaluation of matrine derivatives as potential anticancer agents

Using matrine (1) as the lead compound, a series of new 14-(N-substituted-2-pyrrolemethylene) matrine and 14-(N-substituted-indolemethylene) matrine derivatives was designed and synthesized for their potential application as anticancer agents. The structure of these compounds was characterized by 1H NMR, 13C NMR and ESI-MS spectral analyses. The target compounds were evaluated for their in vitro cytotoxicity against three human cancer cell lines (SMMC-7721, A549 and CNE2). The results revealed that compound A6 and B21 displayed the most significant anticancer activity against three cancer cell lines with IC50 values in range of 3.42–8.05 μM, which showed better activity than the parent compound (Matrine) and positive control Cisplatin. Furthermore, the Annexin V-FITC/PI dual staining assay revealed that compound A6 and B21 could significantly induce the apoptosis of SMMC-7721 and CNE2 cells in a dose-dependent manner. The cell cycle analysis also revealed that compound A6 could cause cell cycle arrest of SMMC-7721 and CNE2 cells at G2/M phase.

Structure-activity relationship of pyrrolyl diketo acid derivatives as dual inhibitors of HIV-1 integrase and reverse transcriptase ribonuclease H domain

The development of HIV-1 dual inhibitors is a highly innovative approach aimed at reducing drug toxic side effects as well as therapeutic costs. HIV-1 integrase (IN) and reverse transcriptase-associated ribonuclease H (RNase H) are both selective targets

Diketo acids derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H Domain

The HIV-1 integrase (IN) and reverse transcriptase (RT) are essential enzymes in the virus cycle. RT is crucial for the retrotranscription of the RNA viral genome, while IN is involved in the insertion in host chromosome of the proviral double strand DNA produced by RT. This enzyme has two associated functions: the RNA- and DNA-dependent DNA polymerase (RDDP and DDDP) and the ribonuclease H (RNase H). The RNase H function catalyzes the selective hydrolysis of the RNA strand of the RNA:DNA heteroduplex replication intermediate. Since the discovery that catalytic cores of both HIV-1 RNase H and IN are folded in a very similar way, have very similar active site geometries, and show the same DDE triad absolutely required for catalytic activity, some researches were devoted to study IN and RNase H dual inhibitor. Our decennial interest in design and synthesis of IN inhibitors led us to study the activity of our compounds also on RNase H activity. The results of the activities showed by pyrrolyl and quinolonyl diketo acids are reported and discussed.