883566-52-7

Upstream product

• 39161-84-7 4-mercaptophenylacetic acid 
• 76-83-5 trityl chloride 

Downstream Products

• 1181208-62-7 C₃₈H₄₄N₂O₅S 
• 1392223-10-7 N-(4-nitrobenzyl)-2-(4-(tritylthio)phenyl)acetamide 
• 1392223-12-9 S-(4-(2-((4-nitrobenzyl)amino)-2-oxoethyl)phenyl) (E)-3-(2-(14,14-dimethyl-12-oxo-2,5,8,13-tetraoxa-11-azapentadecyl)-4-(methoxymethoxy)phenyl)prop-2-enethioate 
• 1392223-11-8 2-(4-mercaptophenyl)-N-(4-nitrobenzyl)acetamide 

Relevant academic research and scientific papers

Direct on-resin synthesis of peptide-αthiophenylesters for use in native chemical ligation

A peptide-αthiophenylester is a key reactant in native chemical ligation. Preformation of the peptide-αthiophenylester could be useful for enhancing the ligation reaction. We report the direct on-resin preparation of preformed peptid

Spontaneously cleavable glycosylated linker capable of extended release of its conjugated peptide

Reversibly glycosylated conjugates were developed by adding complex-type N-linked oligosaccharides to peptides through self-cleavable linkers with the aim of increasing the solubility and stability of the peptides in plasma. The amino or carboxyl group of the peptide was connected to a glycosylated Ascendis or ester/thioester-type linker, respectively. Use of the linkers enabled extended release of the peptides depending on the pH and temperature of the buffer according to a first order reaction, and their cleavage rate was also affected by the structure of the peptide-linker coupling. This tunability will allow optimization towards the intended use of the peptides to be released. Furthermore, because glycosylation is a reliable method of greatly increasing the solubility of a peptide, the presented glycosylated linkers are expected to permit the preparation of antibodies in aqueous buffers even in the case of sparingly soluble antigen peptides.

METHOD FOR PATHOGENS, MICROORGANISMS, AND PARASITES INACTIVATION

The invention provides a method for inactivation or reduction of pathogens, microorganisms or parasites in a sample, media, composition, utility, device, surface or organism by treatment with an alkylating compound of Structure I, followed by elimination or reduction of the residual compound with Structure I by treatment with a neutralizing agent, which eliminates or reduces the toxicity or other undesirable properties of the alkylating compound with Structure I. The neutralizing agent may be present in a treatment solution or be part of a solid-phase agent, and preferably acts by eliminating the alkylating properties of the compound of Structure I.

HF-Free Boc Synthesis of Peptide Thioesters for Ligation and Cyclization

We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF. Boc in situ neutralization protocols are used in combination with Merrifield hydroxymethyl resin and TFA/TMSBr cleavage. Avoiding HF extends the scope of Boc SPPS to post-translational modifications that are compatible with the milder cleavage conditions, demonstrated here with the synthesis of the phosphorylated protein CHK2. Peptide thioesters give easy, direct, access to cyclic peptides, illustrated by the synthesis of cyclorasin, a KRAS inhibitor.

SUGAR CHAIN-ATTACHED LINKER, COMPOUND CONTAINING SUGAR CHAIN-ATTACHED LINKER AND PHYSIOLOGICALLY ACTIVE SUBSTANCE OR SALT THEREOF, AND METHOD FOR PRODUCING SAME

To provide a carrier linker that is capable of improving the water solubility of a physiologically active substance and more quickly releasing the physiologically active substance under specific conditions without utilizing light or enzymatic cleavage. [S

Development of protein-labeling probes with a redesigned fluorogenic switch based on intramolecular association for no-wash live-cell imaging

Turn on the switch: Fluorogenic probes for protein labeling based on the photoactive yellow protein (PYP) tag were developed. The fluorescence of the probes is turned off by intramolecular association and switched on by the reversal of this interaction up

Colorimetric screening of bacterial enzyme activity and inhibition based on the aggregation of gold nanoparticles

A simple and novel gold nanoparticle (Au-NPs) based colorimetric method has been developed for efficient screening of class A β-lactamase (Bla) activity and inhibitors in vitro and in bacterial strains.

METHODS AND COMPOUNDS FOR DETECTING BETA-LACTAMASE ACTIVITY

The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises a metal or a combination of metals, or it comprises a nanot