88357-10-2

Basic information

• Product Name: Propanoic acid, 3-[(4-formylphenyl)thio]-
• CAS NO: 88357-10-2
• Molecular Formula: C10H10O3S
• Molecular Weight: 210.254
• Mol File: 88357-10-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 3-[(4-formylphenyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 3-[(4-formylphenyl)thio]-(88357-10-2)
• EPA Substance Registry System: Propanoic acid, 3-[(4-formylphenyl)thio]-(88357-10-2)

Safety Data

• Hazardous Substances Data: 88357-10-2(Hazardous Substances Data)

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 37794-15-3 p-methylsulfinylbenzaldehyde 
• 141-76-4 3-iodopropanoic acid 

Relevant articles and documents

3-(4-Hydroxymethylphenylsulfanyl)propanoic acid (HMPPA) as a new safety catch linker in solid phase peptide synthesis

A new safety catch linker, 3-(4-hydroxymethylphenylsulfanyl)propanoic acid (HMPPA), is described for use in solid phase peptide synthesis. The linker is readily synthesized from commercially available chemicals in a more cost efficient way compared to similar reported linkers. The HMPPA linker is easily attached to an amino derivatized solid support followed by on-resin oxidation of the thioether to sulfoxide, thereby making the linker very stable towards strong acid treatment. Final resin cleavage is performed by reductive acidolysis.