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Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1, selectively targeting CB1 over CB2 with high affinity (Ki = 178 nM; Kb = 66.6 nM). It exhibits no activity at CB2 receptors up to concentrations of 10 μM and also functions as an antagonist of GPR18 (IC50 = 3.74 μM). Additionally, amauromine possesses vasodilatory properties.

88360-87-6

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88360-87-6 Usage

Uses

Used in Pharmaceutical Industry:
Amauromine is used as a CB1 antagonist for its potential therapeutic applications in treating various conditions related to the endocannabinoid system, such as obesity, metabolic disorders, and neurodegenerative diseases. Its selectivity for CB1 over CB2 may offer advantages in targeting specific physiological pathways without affecting other receptor subtypes.
Used in Cardiovascular Applications:
Amauromine is used as a vasodilator to improve blood flow and reduce peripheral vascular resistance, which can be beneficial in managing conditions such as hypertension and angina. Its vasodilatory activity may also contribute to its potential use in treating other cardiovascular diseases.
Used in Research and Development:
Amauromine is used as a research tool to study the role of CB1 receptors and GPR18 in various physiological and pathological processes. Its antagonistic properties allow researchers to investigate the effects of blocking these receptors, providing valuable insights into their functions and potential therapeutic targets.

Check Digit Verification of cas no

The CAS Registry Mumber 88360-87-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,3,6 and 0 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88360-87:
(7*8)+(6*8)+(5*3)+(4*6)+(3*0)+(2*8)+(1*7)=166
166 % 10 = 6
So 88360-87-6 is a valid CAS Registry Number.

88360-87-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name Amauromine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:88360-87-6 SDS

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