88369-26-0Relevant academic research and scientific papers
COMPOSITIONS AND METHODS FOR REDUCING TACTILE DYSFUNCTION, ANXIETY, AND SOCIAL IMPAIRMENT
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Page/Page column 21; 41-42, (2020/10/20)
The present invention provides novel peripherally-restricted benzodiazepines with reduced blood brain barrier permeability and methods of use thereof for reducing tactile dysfunction, social impairment, and anxiety in a subject diagnosed with Autism Spectrum Disorder, Rett syndrome, Phelan McDermid syndrome, or Fragile X syndrome.
Biocatalytic deracemization of 1,4-benzodiazepines in the synthesis of enantiomerically pure serine
Avdagic, Amir,Sunjic, Vitomir
, p. 85 - 92 (2007/10/03)
An efficient stereocontrolled synthesis of (S)-N-Cbz-serine (Cbz = benzyloxycarbonyl; 12) and of its (R)-enantiomer is reported. Kinetic resolution of the easily available racemic 3-(hydroxymethyl)-1,4- benzodiazepin-2-ones is performed in the key step via acetylation by the immobilized Mucor miehei lipase (Lipozyme IM) at 60°. This method is characterized by high enantiomer purity (ee's ≤ 99%) of the intermediary alcohols (+)-8 and (+)-9 and acetates (-)-10 and (-)-11, as well as of the final products (s)- and (R)-N-Cbz-serine, simple recycling of the biocatalyst, complete recovery of 2-aminobenzophenones (3 and 4) and their recycling into production of 1,4-benzodiazepines, and possibility to selectively racemize 'wrong' enantiomers of the alcohols 8 and 9 in the presence of Amberlite CG 400.
Chiral 1,4-benzodiazepines. XII (1). Conformation in a solution of 7-chloro-5-phenyl-3(S)methyl-1,3-dihydro-2H-1,4-benzodiazepine
Decorte,Toso,Fajdiga,et al.
, p. 1321 - 1327 (2007/10/02)
Deuterium labeled congeners of 7-chloro-5-phenyl-3(S)-methyl-1,3-dihydro-2H-1,4-benzodiazepine (8), i.e. compounds 9 and 16-18 were prepared and their lis-nmr spectra run. For computational studies compounds 9 and 16 were chosen. The results of lis measur
