88369-59-9 Usage
Chemical Category
Quinazolinones
Molecular Weight
222.24 g/mol
Type of Compound
Heterocyclic organic compound
Backbone Structure
Pyridoquinazoline
Amino Group Position
6th position
Pharmaceutical Applications
Building block in the synthesis of bioactive compounds and pharmaceutical drugs
Therapeutic Properties
Potential therapeutic properties
Ongoing Research
Research for potential use in the treatment of various diseases and conditions
Structure
The compound has a fused six-membered pyridine ring and a seven-membered quinazoline ring, with an amino group attached to the 6th position of the quinazoline ring.
Functional Groups
The compound contains an amide functional group (C=O) and an amino group (-NH2) as part of its structure.
Solubility
The solubility of the compound may vary depending on the solvent used, but it is generally more soluble in polar solvents such as water or alcohols.
Stability
The compound is stable under normal conditions, but it may be sensitive to heat, light, or moisture, which could lead to degradation or decomposition.
Reactivity
The compound may react with strong acids, strong bases, or other reactive chemicals, which could alter its structure or properties.
Check Digit Verification of cas no
The CAS Registry Mumber 88369-59-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,3,6 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 88369-59:
(7*8)+(6*8)+(5*3)+(4*6)+(3*9)+(2*5)+(1*9)=189
189 % 10 = 9
So 88369-59-9 is a valid CAS Registry Number.
88369-59-9Relevant articles and documents
New Synthesis of 11-Acyl-5,11-dihydro-6H-pyridobenzodiazepin-6-ones and Related Studies
Kovac, T.,Oklobdzija, M.,Comisso, G.,Decorte, E.,Fajdiga, T.,et al.
, p. 1339 - 1349 (2007/10/02)
New synthesis of 11-acyl-5,11-dihydro-6H-pyridobenzodiazepin-6-ones (42-44) is reported.The crucial steps (Scheme VI) represented N-oxidation of 1 (1A) to 35 (35A), facilitated ring-closure of 36 into 37, its subsequent N-α-chloroacetylation to 38, aminolysis to 39-41 (involving N-O anchimeric assistance as depicted in 38A) and deoxygenation to 42-44 (Scheme VII).The central intermediate 37 is also obtained on oxygenation of 2, a new synthesis of which was reported in the previous paper of this series .Other attempts of cyclisation "from the top" or "from the bottom" (Scheme I) are described.Thus, interaction of 1 with acetamide afforded 3 and 4 instead of the expected 2A.Compound 5 cyclised into 3-pyridoquinazolone 6 while its 2-(4'-methylpiperazin-1'-yl) analogue 9 was observed to be unstable for the attempted ring-opening and reclosure to 42. "From the bottom" cyclisations of 10A-10C, via intermediary amines 11A-11C failed and pyridoquinazolinone 13 was isolated (Scheme V).The attempted oxidative cyclisation of the compounds 15 and 18 into 2 and 42, respectively, 13 afforded imidazolopyridine derivative (18-19), while 15 remained unchanged. 3-Acylamino-2-arylaminopyridines (21-24), cyclised into the imidazolopyridines 29-30.Model compounds 45-50 were prepared to study selective aminolysis of the chlorine atoms in 2-chloro-3-(2'-chlorobenzoyl)aminopyridine 1, and its N-oxide 35.
