883720-01-2Relevant academic research and scientific papers
Synthesis and cytotoxicity screening of substituted isobenzofuranones designed from anacardic acids
Logrado, Lucio P.L.,Santos, Camila O.,Romeiro, Luiz A.S.,Costa, Arinice M.,Ferreira, Jose R.O.,Cavalcanti, Bruno C.,Moraes, O. Manoelde,Costa-Lotufo, Leticia V.,Pessoa, Claudia,Dos Santos, Maria L.
, p. 3480 - 3489 (2010)
This work is part of a large program,which seeks to discover new antitumor isobenfuranones designed from anacardic acids. The synthetic strategy for the construction of the title compounds takes into consideration the use of inexpensive anacardic acids (2),the major natural cashew (Anacardium occi-dentale) nut-shell phenolic lipid,and features one-pot construction of fused-ring aromatic g-lactones,phthalides. The cytotoxicity screening in different human cancer cell lines (HL-60 leukemia,SF295 glioblastoma and MDA-MB435 melanoma) by the MTT assay showed that acyclic precursor (6),and isobenfuranones (1a and 1b) are active compounds. Interestingly,1a exhibits significant antiproliferative effect against HL-60 cells and moderate activity against SF295 and MDA-MB435 cell lines. Analysis of mechanisms involved in the cytotoxic activity showed that active compounds were leading to DNA damage,triggering apoptosis or necrosis induction.
