883733-65-1Relevant academic research and scientific papers
Rational design of an apoptosis-inducing photoreactive DNA intercalator
Ueberschaar, Nico,Dahse, Hans-Martin,Bretschneider, Tom,Hertweck, Christian
, p. 6185 - 6189 (2013)
Light on DNA intercalators: Molecular modeling and mutasynthesis were employed to rationally tailor the antitumoral agent chartreusin into a vinyl-substituted derivative. Exposure with visible light dramatically improved antiproliferative activities owing to covalent binding with DNA and induction of apoptosis. The results hold promise for a more efficient chemotherapy, in particular for selectively treating tumors with light probes. Copyright
Directed ortho and Remote Metalation–Suzuki–Miyaura Cross Coupling Route to Azafluorenol Core Liquid Crystals
Lai, Ping-Shan,Jansen-Van Vuuren, Ross D.,Lemieux, Robert P.,Snieckus, Victor
, p. 17543 - 17549 (2021/12/13)
Two new smectic C* mesogens containing a hexyloxy side chain and an azafluorenone (3a) or azafluorenol (3b) core were synthesized using a combined directed ortho metalation-directed remote metalation–Suzuki–Miyaura cross-coupling strategy. 3b was formed i
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics
Aujay, Monette,Das, Dipendu,Gavrilyuk, Julia,Hammond, Mikhail,Lu, Yong,Lyssikatos, Joseph,Nicolaou, K. C.,Pitsinos, Emmanuel N.,Rout, Subhrajit,Sandoval, Joseph,Schammel, Alexander
, (2020/02/13)
The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the family of tiancimycins A-
NOVEL CHARTREUSIN ANALOGUES
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Page/Page column 12; 24; 25, (2014/02/16)
The present invention relates to novel Chartreusin analogues of formula (I), pharmaceutical compositions comprising the same and to their use for the treatment of cancer and other diseases.
The cobalt way to angucyclinones: Asymmetric total synthesis of the antibiotics (+)-rubiginone B2, (-)-tetrangomycin, and ( - ) -8- O-Methyltetrangomycin
Kesenheimer, Christian,Kalogerakis, Aris,Meissner, Anja,Groth, Ulrich
experimental part, p. 8805 - 8821 (2010/10/21)
A cobalt(I)-mediated convergent and asymmetric total synthesis of angucyclinones with an aromatic B ring has been developed. In the course of our research, we synthesized three naturally occurring anguclinone derivatives, namely, (+)-rubiginone B2/s
