883740-41-8Relevant academic research and scientific papers
Synthesis of benzo-fused medium ring cyclic ethers via a Michael addition-ring closing metathesis strategy involving nitroaliphatic compounds
Deb, Indubhusan,John, Sumod,Namboothiri, Irishi N.N.
, p. 11991 - 11997 (2007)
Nitroalkenes derived from O-protected salicylaldehyde undergo facile Michael-type addition of nucleophiles possessing unsaturated tether. Ring closing metathesis of the Michael adducts provides benzo-fused medium ring cyclic ethers possessing a nitroalkyl
Highly enantioselective synthesis of chiral 7-ring O- and N-heterocycles by a one-pot nitro-Michael-cyclization tandem reaction
Rohlmann, Renate,Daniliuc, Constantin-Gabriel,Mancheno, Olga Garcia
, p. 11665 - 11667 (2013/12/04)
A concise enantioselective approach to synthesise medium-sized 7-ring O- and N-heterocycles has been developed. The synthetic strategy relies on an organocatalytic nitro-Michael-nitrile oxide cycloaddition tandem reaction, leading to the corresponding chiral benzoxe- and benzazepine derivatives containing an additional fused dihydroisoxazoline ring in good yields and excellent enantioselectivities (up to 97% ee).
Synthesis of nitroalkenes involving a cooperative catalytic action of iron(III) and piperidine: A one-pot synthetic strategy to 3-alkylindoles, 2H-chromenes and N-arylpyrrole
Jalal, Swapnadeep,Sarkar, Soumen,Bera, Krishnendu,Maiti, Sukhendu,Jana, Umasish
supporting information, p. 4823 - 4828 (2013/08/23)
An efficient and simple strategy has been developed to synthesize various substituted nitroalkenes involving a cooperative catalytic system of FeCl 3 and piperidine. This dual catalytic protocol simultaneously activates both electrophile and nucleophile and works under mild reaction conditions so that many sensitive functional groups were tolerated. Moreover, this cooperative catalytic reaction is also suitable for various one-pot reactions involving nitroalkenes such as, 2H-chromenes, N-arylpyrrole and Michael reaction with indole. Notably, this method is low-cost, efficient and environmentally friendly. Copyright
Stereoselective synthesis of isoxazolinobenzoxepanes via intramolecular nitrile oxide cycloaddition
Ramachandiran,Karthikeyan,Nandhakumar,Muralidharan,Perumal
scheme or table, p. 3277 - 3286 (2011/11/29)
Concise routes to the synthesis of indole-tethered nitrile oxides have been developed, and their intramolecular nitrile oxide cycloadditions were studied. Heterocyclic scaffolds involving isoxazolinobenzoxepane frameworks have been achieved via intramolecular nitrile oxide cycloaddition of 3-[1-(2- allyloxyphenyl)-2-nitroethyl]-1H-indole derivatives using (Boc)2O and DMAP. This protocol affords products with excellent trans-selectivity. Georg Thieme Verlag Stuttgart · New York.
