883838-74-2Relevant academic research and scientific papers
Highly Diastereo- and Enantioselective Michael Addition of Nitroalkanes to 2-Enoyl-Pyridine N-Oxides Catalyzed by Scandium(III)/Copper(II) Complexes
Li, Lijun,Zhang, Sheng,Hu, Yanbin,Li, Yanan,Li, Chong,Zha, Zhenggen,Wang, Zhiyong
, p. 12885 - 12888 (2015/09/07)
A C2-symmetric Schiff-base ligand, derived from tridentate-Schiff-base, was developed and successfully applied to the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides. With this newly catalytic system, an unprecedented diastereoselectivity was obtained in the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides. In addition, a switch in enantioselectivity was achieved by using this newly catalytic system and our previous catalyst. After a facile reduction, the optically active adduct was converted to a biologically active dihydro-2H-pyrrol 4a. Furthermore, a connection of two tridentate-Schiff-base subunits proved to be an effective strategy in ligand design. Complex chemistry! A C2-symmetric Schiff-base ligand, derived from tridentate-Schiff-base, was developed and successfully applied to the asymmetric Michael addition of nitroalkanes to 2-enoyl-pyridine N-oxides with unprecedented diastereoselectivity (see scheme).
Highly enantioselective Friedel-Crafts reaction of indoles with 2-enoylpyridine 1-oxides catalyzed by chiral pyridine 2,6-bis(5′,5′- diphenyloxazoline)-Cu(II) complexes
Singh, Pradeep K.,Singh, Vinod K.
supporting information; experimental part, p. 4121 - 4124 (2009/05/27)
(Chemical Equation Presented) The catalytic enantioselective Friedel-Crafts reaction of indoles with 2-enoylpyridine 1-oxides has been studied in the presence of chiral pyridine 2,6-bis(5′,5′-diphenyloxazoline)-Cu(II) complexes. The reaction furnished alk
