883908-16-5

Basic information

• Product Name: 4-{4-bromo-2-[2-(7-methoxy-2-oxo-2H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester
• CAS NO: 883908-16-5
• Molecular Weight: 572.456
• Mol File: 883908-16-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-{4-bromo-2-[2-(7-methoxy-2-oxo-2H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-bromo-2-[2-(7-methoxy-2-oxo-2H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester(883908-16-5)
• EPA Substance Registry System: 4-{4-bromo-2-[2-(7-methoxy-2-oxo-2H-chromen-4-yl)-acetylamino]-phenyl}-piperazine-1-carboxylic acid tert-butyl ester(883908-16-5)

Safety Data

• Hazardous Substances Data: 883908-16-5(Hazardous Substances Data)

Upstream product

• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 474329-57-2 4-(4-bromo-2-nitro-phenyl)-1-tert-butoxycarbonyl-piperazine 
• 474329-58-3 4-(2-amino-4-bromo-phenyl)-1-tert-butoxycarbonyl-piperazine 
• 62935-72-2 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid 

Relevant articles and documents

BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: Chromene, coumarin and quinoline

The protease β-secretase plays a central role in the synthesis of pathogenic amyloid-β in Alzheimer's disease. Here, we report a new series of analogues based on the phenyl-piperazine scaffold coupled to various heterocyclic moieties, which demonstrate improved inhibitory activities on BACE-1 (FRET assay) compared to already known naphthyl counterparts. The obtained results suggest further structural modifications to access to more potent BACE-1 inhibitors.