883974-07-0Relevant academic research and scientific papers
Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase
Lai, Chunqiu,Gum, Rebecca J.,Daly, Melissa,Fry, Elizabeth H.,Hutchins, Charles,Abad-Zapatero, Celerino,Von Geldern, Thomas W.
, p. 1807 - 1810 (2007/10/03)
A series of novel benzoxazole benzenesulfonamides was synthesized as inhibitors of fructose-1,6-bisphosphatase (FBPase-1). Extensive SAR studies led to a potent inhibitor, 53, with an IC50 of 0.57 μM. Compound 17 exhibited excellent bioavailabi
