N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride, also known as M8-B Hydrochloride, is a chemical compound that acts as an antagonist of the transient receptor potential melastatin 8 (TRPM8) channel. It effectively blocks the activation of TRPM8 by cold, icilin, or menthol in vitro, with IC50 values of 7.8, 26.9, and 64.3 nM, respectively. However, it does not exhibit any effect on other TRP channels. M8-B Hydrochloride has been observed to decrease deep body temperature in wild-type mice and rats, but it does not affect body temperature in TRPM8 knockout mice.
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Basic information
- Product Name: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
- Synonyms: M8-B hydrochloride;N-(2-Aminoethyl)-N-(4-(benzyloxy)-3-methoxybenzyl)thiophene-2-carboxamide hydrochloride;N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride;2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, monohydrochloride;M8-B
- CAS NO:883976-12-3
- Molecular Formula: C22H25ClN2O3S
- Molecular Weight: 432.9635
- EINECS: N/A
- Product Categories: N/A
- Mol File: 883976-12-3.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: white to beige/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: H2O: soluble2mg/mL, clear (warmed)
- CAS DataBase Reference: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride(883976-12-3)
- EPA Substance Registry System: N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride(883976-12-3)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany: 3
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 883976-12-3(Hazardous Substances Data)
883976-12-3 Usage
Uses
Used in Pharmaceutical Industry:N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride is used as a channel blocker for the cold receptor TRPM8. It is particularly useful in the development of drugs targeting the TRPM8 channel for various therapeutic applications, such as pain management and temperature regulation disorders.
Used in Research Applications:
In the field of scientific research, M8-B Hydrochloride serves as a valuable tool for studying the role of TRPM8 channels in various physiological processes and their potential involvement in disease mechanisms. By blocking the TRPM8 channel, researchers can gain insights into the underlying pathways and develop targeted therapies for related conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 883976-12-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,9,7 and 6 respectively; the second part has 2 digits, 1 and 2 respectively.Calculate Digit Verification of CAS Registry Number 883976-12:
(8*8)+(7*8)+(6*3)+(5*9)+(4*7)+(3*6)+(2*1)+(1*2)=233
233 % 10 = 3
So 883976-12-3 is a valid CAS Registry Number.
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N-(2-Aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide hydrochloride
