88398-97-4

Basic information

• Product Name: 1H-Pyrazole-3-sulfonamide,1-methyl-(9CI)
• Synonyms: 1H-Pyrazole-3-sulfonamide,1-methyl-(9CI);1-Methyl-1H-Pyrazole-3-sulfonaMide
• CAS NO: 88398-97-4
• Molecular Formula: C4H7N3O2S
• Molecular Weight: 161.18228
• Product Categories: SULFONAMIDE
• Mol File: 88398-97-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrazole-3-sulfonamide,1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-sulfonamide,1-methyl-(9CI)(88398-97-4)
• EPA Substance Registry System: 1H-Pyrazole-3-sulfonamide,1-methyl-(9CI)(88398-97-4)

Safety Data

• Hazardous Substances Data: 88398-97-4(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
1H-Pyrazole-3-sulfonamide,1-methyl-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block in the development of new drugs.
Used in Pharmaceutical Research:
1H-Pyrazole-3-sulfonamide,1-methyl-(9CI) is used as a research tool in the discovery and optimization of new therapeutic agents. Its potential biological activities and therapeutic applications are being extensively studied to identify its role in the treatment of various diseases and conditions.
Used in Drug Development:
1H-Pyrazole-3-sulfonamide,1-methyl-(9CI) is used as a lead compound in the development of new drugs. Its promising properties and potential applications make it a valuable candidate for further research and development in the pharmaceutical industry.

Upstream product

• 89501-90-6 1-methyl-1H-pyrazole-3-benzenesulfonyl chloride 
• 1904-31-0 methyl-1 amino-3 pyrazole 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors

The antiapoptotic protein Bcl-2, overexpressed in many tumor cells, is an attractive target for potential small molecule anticancer drug discovery. Herein, we report a different structural modification approach on ABT-263 by merging the piperazinyl-phenyl fragment into a bicyclic framework leading to a series of novel analogues, among which tetrahydroisoquinoline 13 was nearly equally potent against Bcl-2 as ABT-263. Further SAR in the P4-interaction pocket affored the difluoroazetidine substituted analogue 55, which retained good Bcl-2 activity with improved Bcl-2/Bcl-xL selectivity.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

NOVEL COMPOUNDS

The present invention relates to novel NADPH oxidase II inhibitors and their use in the treatment of diseases mediated by the NADPH oxidase enzymes.

Herbicidal diazoles sulfonamides

This invention relates to herbicidal heterocyclic aminocarbonyl diazole sulfonamides compounds, compositions thereof and a method for their use to control the growth of undesired vegetation.