883981-75-7Relevant articles and documents
Discotic liquid crystals of transition metal complexes 42?: The detailed phase structures and phase transition mechanisms of two Cub mesophases shown by discotic liquid crystals based on phthalocyanine metal complexes
Mukai, Hidetomo,Yokokawa, Miho,Ichihara, Masahiro,Hatsusaka, Kazuaki,Ohta, Kazuchika
scheme or table, p. 188 - 197 (2010/11/03)
We found in our previous works that the sandwich-type phthalocyanine-based rare earth metal complexes, bis[2,3,9,10,16,17,23,24-octakis(3,4- dialkoxyphenoxy)phthalocyaninato]lanthanoid(III) ({[(CnO) 2PhO]8Pc}2M,
Desferrithiocin analogues and nephrotoxicity
Bergeron, Raymond J.,Wiegand, Jan,McManis, James S.,Bharti, Neelam,Singh, Shailendra
experimental part, p. 5993 - 6004 (2009/10/01)
The syntheses of a series of 4′-O-alkylated (S)-4,5-dihydro-2-(2,4- dihydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid and 5′-O-alkylated (S)-4,5-dihydro-2-(2,5-dihydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid ligands are described. Their partition between octanol and water, log P app, is determined, along with their iron-clearing efficiency (ICE) in both non-iron-overloaded, bile duct-cannulated rodents and in iron-overloaded primates. The ligand-promoted biliary ferrokinetics in rats are described for each of the chelators. Plots of log Papp versus ICE in a rodent model for both the 4′-O-alkylated 2,4-dihydroxy and 5′-O-alkylated 2,5-dihydroxy series produced an inverse parabola plot with r2 values of 0.97 and 0.81, respectively. The plots indicate an optimum log P app/ICE relationship. Because of the nature of the data spread in the 4′-O-alkylated 2,4-dihydroxy series, it will be used to help assess the origin of nephrotoxicity in desferrithiocin analogues: is toxicity simply related to lipophilicity, ICE, or a combination of these properties?
