884-27-5 Usage
Structure
Benzene derivative with a bromine atom and a 2-methylbenzyl group
Explanation
The compound is derived from benzene, which is a six-carbon ring with alternating single and double bonds. A bromine atom is attached to the first carbon of the benzene ring, and a 2-methylbenzyl group (a benzyl group with a methyl group at the 2nd position) is connected to the second carbon.
Explanation
1-bromo-2-(2-methylbenzyl)benzene is used in the synthesis of various organic compounds, particularly in the production of pharmaceuticals and agrochemicals.
Explanation
The compound serves as a starting material or building block for the synthesis of other aromatic compounds, which can be used in various applications.
Explanation
1-bromo-2-(2-methylbenzyl)benzene is used in research and development processes within the chemical industry to explore new reactions, syntheses, and applications.
Explanation
The compound has the potential to be used as a precursor in the synthesis of polymers and other materials, which can have various applications in different industries.
Explanation
Most organic compounds with a molecular weight similar to 1-bromo-2-(2-methylbenzyl)benzene are solids or liquids at room temperature. However, the exact physical state would depend on the specific conditions and purity of the compound.
Explanation
Due to its nonpolar nature, 1-bromo-2-(2-methylbenzyl)benzene is likely soluble in organic solvents such as dichloromethane, ethyl acetate, or toluene.
Explanation
The compound is expected to be stable under normal conditions, such as room temperature and pressure, and in the absence of strong acids, bases, or oxidizing agents.
Explanation
As with many organic compounds, 1-bromo-2-(2-methylbenzyl)benzene may pose health risks if not handled properly. It could be an irritant or toxic, and appropriate safety measures should be taken when working with 1-bromo-2-(2-methylbenzyl)benzene.
Application
Organic synthesis
Use as a building block
Synthesis of aromatic compounds
Utilization
Research and development in the chemical industry
Potential use
Precursor in the production of polymers and other materials
Physical state
Likely a solid or liquid at room temperature
Solubility
Soluble in organic solvents
Stability
Stable under normal conditions
Hazards
Potential irritant or toxic
Check Digit Verification of cas no
The CAS Registry Mumber 884-27-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 8,8 and 4 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 884-27:
(5*8)+(4*8)+(3*4)+(2*2)+(1*7)=95
95 % 10 = 5
So 884-27-5 is a valid CAS Registry Number.
884-27-5Relevant academic research and scientific papers
Efficient palladium-catalyzed C(sp2)-H activation towards the synthesis of fluorenes
Song, Juan,Li, Yali,Sun, Wei,Yi, Chenglong,Wu, Hao,Wang, Haotian,Ding, Keran,Xiao, Kang,Liu, Chao
supporting information, p. 9030 - 9033 (2016/11/11)
A facile protocol for the synthesis of fluorene derivatives has been developed through palladium-catalyzed cyclization of 2′-halo-diarylmethanes via activation of arylic C-H bonds. The reactions occurred smoothly and allowed both electron-rich and electron-deficient substrates to convert into their corresponding fluorenes in good to excellent yields. Studies revealed that this Pd-catalyzed cyclization was also available for the substrates of 2′-chloro-diarylmethanes and no catalyst poisoning occurred for 2′-iodo-diphenylmethane.
Bismuth-catalyzed synthesis of anthracenes via cycloisomerization of o-alkynyldiarylmethane
Park, Jungmin,Choi, Hyuck,Lee, Deug-Chan,Lee, Kooyeon
supporting information, p. 7005 - 7007 (2015/11/27)
In this study, anthracenes were efficiently synthesized from o-alkynyldiarylmethane using a novel method that exploits the synergistic effect between Bi(OTf)3 as the catalyst, and trifluoroacetic acid (TFA). Through this reaction, we achieved the rapid and efficient synthesis of anthracenes bearing various functional groups under mild conditions.
Synthesis of methylene-bridge polyarenes through palladium-catalyzed activation of benzylic carbon-hydrogen bond
Hsiao, Chien-Chi,Lin, Yi-Kuan,Liu, Chia-Ju,Wu, Tsun-Cheng,Wu, Yao-Ting
supporting information; experimental part, p. 3267 - 3274 (2011/02/23)
In the presence of palladium(II) acetate [Pd(OAc)2] and an N-heterocyclic carbene (NHC) ligand, fluorene derivatives can be generated in good to excellent yields from 2-halo-2′-methylbiaryls through the benzylic C-H bond activation (14 examples; 81-97% yields). The scope and limitations of this protocol have been examined. A wide range of functional groups, such as alkyl, alkoxy, ester, nitrile, and others, is able to tolerate the reaction conditions herein. The cyclization of an isotope-labelled biphenyl gave the corresponding product with a primary kinetic isotope effect (k H/kD=4.8:1), which indicates that the rate-determining step of this reaction is the activation of the benzylic C-H bond. Moreover, indenofluorenes were also accessed in excellent results from terphenyls (3 examples; 91-92% yields). The cascade reaction of 2,6-dichloro-2′- methylbiphenyl with diphenylacetylene produced 8,9-diphenyl-4H-cyclopenta[def] phenanthrene in 60% yield through the activation of an aryl and a benzylic C-H bond. Copyright
