88406-78-4Relevant academic research and scientific papers
6H-THIAZINES-1,3 SUBSTITUEES EN POSITION 2 PAR UN GROUPEMENT LABILE, ELECTROPHILES AMBIDENTS
Tea-Gokou, C.,Pradere, J. P.,Villieras, J.,Quiniou, H.
, p. 3713 - 3716 (1983)
Substitution by H2O in the presence of HCl and by NH(CH3)2 occurs at position 2 of 5-acetyl-2-benzylthio-6H-1,3-thiazine without ring opening (in the first step for the amine).Substitution by the softer anion derived from diethylmalonate (and most likely HS-) occurs at position 6 with ring-opening.Subsequent cyclisations give the corresponding thiocarbonyl compounds.All these reactions are accompanied by elimination of the labile benzylthio group.
Synthesis of thiaazaheterocycle nucleoside analogues
Ane,Prestat,Thiam,Josse,Pipelier,Pradere,Dubreuil
, p. 335 - 360 (2007/10/03)
The syntheses of thiazinone, thiazinedione and thiazolinone base modified nucleoside analogues have been discussed in both the deoxy- and ribosyl series. Both inter- and intramolecular N-glycosylations were evaluated.
PROPRIETES ELECTROPHILES DES 6H-THIAZINES-1,3 SUBSTITUEES
Tea,Gokou,Pradere, Jean-Paul,Bujoli, Bruno,Quiniou, Herve,Toupet, Loic
, p. 149 - 157 (2007/10/02)
The electrophilic properties of the ambident 1,3-substituted 6H-thiazines (C2 and C6 carbons) are shown by the action of amines, water, mercaptans as nucleophiles.By such reactions dithiocarbamates, thioamides and thioureas are readily obtained.The regios
