88426-35-1Relevant articles and documents
Microbial transformations of natural antitumor agents. XXII: Conversion of bouvardin to O-desmethylbouvardin and bouvardin catechol
Petroski,Bates,Linz,Rosazza
, p. 1291 - 1294 (1983)
Bouvardin is a cyclic hexapeptide antitumor agent which undergoes two major microbial transformation reactions. Screening with 220 cultures revealed 17 different strains capable of producing O-desmethylbouvardin in good yield. O-Desmethylbouvardin was isolated and characterized from preparative scale incubations with Streptomyces rutgersensis NRRL B-1256. Four aspergilli and one streptomycete formed bouvardin catechol when O-desmethylbouvardin was used as substrate. Bouvardin catechol was isolated and characterized from a preparative scale incubation with Aspergillus ochraceous UI 398.