88427-96-7

Basic information

• Product Name: 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE
• Synonyms: 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE;4-(2-METHYL-1H-IMIDAZOL-1-YL)BENZALDEHYDE;4-(2-METHYLIMIDAZOL-1-YL)BENZALDEHYDE, 95+%;Albb-005605;4-(2-methyl-1-imidazolyl)benzaldehyde;4-(2-methylinidazol-1-yl)benzaldehyde
• CAS NO: 88427-96-7
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 88427-96-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 374.9 °C at 760 mmHg
• Flash Point: 180.6 °C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 8.05E-06mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 6.50±0.10(Predicted)
• CAS DataBase Reference: 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE(88427-96-7)
• EPA Substance Registry System: 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE(88427-96-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 88427-96-7(Hazardous Substances Data)

Usage

General Description

4-(2-Methyl-imidazol-1-yl)-benzaldehyde is a chemical compound with the molecular formula C11H10N2O. It is a yellowish solid with a molecular weight of 186.21 g/mol. 4-(2-METHYL-IMIDAZOL-1-YL)-BENZALDEHYDE is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in organic chemistry reactions, including the formation of heterocyclic compounds. 4-(2-Methyl-imidazol-1-yl)-benzaldehyde has a variety of potential applications due to its chemical properties and structure, and it is an important intermediate in the production of various organic compounds.

InChI:InChI=1/C11H10N2O/c1-9-12-6-7-13(9)11-4-2-10(8-14)3-5-11/h2-8H,1H3

Upstream product

• 693-98-1 2-methylimidazole 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 239073-26-8 4-(tert-butoxycarbonyl)-1-[4-(2-methyl-1H-imidazol-1-yl)benzyl]-2-piperazinone 
• 167758-58-9 4-(2-Methyl-1H-imidazol-1-yl)benzenemethanol 
• 1177252-04-8 1-{(1-benzyl-1H-tetrazol-5-yl)[4-(2-methyl-1H-imidazol-1-yl)phenyl]methyl}-4-cyclobutyl-1,4-diazepane 

Relevant articles and documents

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

GPR142 has been identified as a potential glucose-stimulated insulin secretion (GSIS) target for the treatment of type 2 diabetes mellitus (T2DM). A class of triazole GPR142 agonists was discovered through a high throughput screen. The lead compound 4 suffered from poor metabolic stability and poor solubility. Lead optimization strategies to improve potency, efficacy, metabolic stability, and solubility are described. This optimization led to compound 20e, which showed significant reduction of glucose excursion in wild-type but not in GPR142 deficient mice in an oral glucose tolerance test (oGTT) study. These studies provide strong evidence that reduction of glucose excursion through treatment with 20e is GPR142-mediated, and GPR142 agonists could be used as a potential treatment for type 2 diabetes.