884345-46-4

Upstream product

• 884345-75-9 methyl (5S,7R,8R)-5,8-bis-(tert-butyldimethylsilyloxy)-7-(2-trimethylsilylethoxymethoxy)non-2-ynoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 38996-24-6 (4R,5R)-4,5-dihydro-4-hydroxy-5-methyl-2(3H)-furanone 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 884345-74-8 (4S,6R,7R)-4,7-bis-(tert-butyldimethylsilyloxy)-6-(2-trimethylsilylethoxymethoxy)oct-1-yne 
• 884345-44-2 (4S,6R,7R)-7-tert-butyldimethylsilyloxy-6-(2-trimethylsilylethoxymethoxy)oct-1-yn-4-ol 
• 884345-45-3 (4R,6R,7R)-7-tert-butyldimethylsilyloxy-6-(2-trimethylsilylethoxymethoxy)oct-1-yn-4-ol 
• 884345-42-0 (3R,4R)-4-tert-butyldimethylsilyloxy-3-(2-trimethylsilylethoxymethoxy)pentanoic acid methoxymethylamide 
• 884345-43-1 (3R,4R)-4-tert-butyldimethylsilyloxy-3-(2-trimethylsilylethoxymethoxy)pentanal 

Downstream Products

• 884345-47-5 (8S,10R,11R)-8,11-bis-(tert-butyldimethylsilyloxy)-6-[(E)-2-tertbutyldiphenylsilyloxyethylidene]-3,3-dimethyl-10-(2-trimethylsilylethoxymethoxy)dodec-1-en-4-one 
• 884345-48-6 (8S,10R,11R)-8,11-bis-(tert-butyldimethylsilyloxy)-6-[(E)-2-tert-butyldiphenylsilyloxyethylidene]-3,3-dimethyl-10-hydroxydodec-1-en-4-one 

Relevant academic research and scientific papers

Syntheses of C17-C27 fragments of 20-deoxybryostatins for assembly using Julia and metathesis reactions

Two approaches to the synthesis of compounds corresponding to the C17-C27 fragment of the 20-deoxybryostatins are described. The first approach is based on the palladium(0) catalysed coupling of tin enolates, generated in situ from enol acetates using tri

A preliminary evaluation of a metathesis approach to bryostatins

Preliminary investigations into the synthesis of bryostatins using ring-closing metathesis to form the C(16)-C(17) double bond led to a synthesis of the bryostatin analogue 51; precursors 26 and 52, which possess the geminal dimethyl group at C-18, did no