88442-97-1Relevant articles and documents
Bronsted Acid Catalyzed Cyclization of Inert N-Substituted Pyrroles to Benzo[ f ]pyrrolo[1,2- a ][1,4]diazepines
Gao, Zeng,Qian, Jinlong,Yang, Huameng,Zhang, Jinlong,Jiang, Gaoxi
, p. 930 - 934 (2021/04/27)
Two approaches involving intramolecular and intermolecular cyclization, respectively, have been developed for the direct and practical construction of a series of important benzo[ f ]pyrrolo[1,2- a ][1,4]azepines by using Bronsted acid catalysts. Upon catalysis by TsOH, the intramolecular dehydroxylation/ring closure of 3-hydroxy-2-[2-(1 H -pyrrol-1-yl)benzyl]isoindolin-1-ones provided various racemic benzo[ f ]pyrrolo[1,2- a ][1,4]azepines in high yields. Furthermore, enantioenriched benzo[ f ]pyrrolo[1,2- a ][1,4]azepines were also obtained by chiral phosphoric acid catalyzed intermolecular addition of [2-(1 H -pyrrol-1-yl)phenyl]methanamines to 2-formylbenzoates under mild conditions.
Regioselective synthesis of diversely substituted diazoninones through a post-Ugi gold-catalyzed intramolecular hydroarylation process
Li, Zhenghua,Kumar, Amit,Vachhani, Dipak D.,Sharma, Sunil K.,Parmar, Virinder S.,Van Der Eycken, Erik V.
supporting information, p. 2084 - 2091 (2014/04/17)
A highly efficient approach for the regioselective construction of fused nine-membered rings (diazoninone framework) was developed by employing sequential Ugi and gold-catalyzed intramolecular hydroarylation reactions. The scope of this intramolecular cyc
Synthesis of condensed pyrroloindoles via Pd-catalyzed intramolecular C-H bond functionalization of pyrroles
Seung, Jun Hwang,Seung, Hwan Cho,Chang, Sukbok
supporting information; experimental part, p. 16158 - 16159 (2009/05/08)
A new strategy for the synthesis of condensed hetero- or carbocycles such as pyrroloindoles or fluorenes has been developed that involves the Pd-catalyzed cyclization of readily available N-(2-halobenzyl)pyrroles or their phenyl derivatives. The reaction is proposed to proceed via oxidative addition of benzylic halides to Pd(0) followed by base-assisted C-H bond activation. A broad range of condensed cyclic products could be obtained in good to excellent yields under mild conditions. Copyright
New four-component ugi-type reaction. Synthesis of heterocyclic structures containing a pyrrolo[1,2-a][1,4]diazepine fragment
Ilyn, Alexey P.,Trifilenkov, Andrey S.,Kuzovkova, Julia A.,Kutepov, Sergey A.,Nikitin, Alexandre V.,Ivachtchenko, Alexandre V.
, p. 1478 - 1481 (2007/10/03)
(Chemical Equation Presented) We present a convenient synthesis of novel heterocyclic structures containing pyrrolo[1,2-α][l,4]diazepine fragment using a novel modification of four-component Ugi condensation. We demonstrate the usefulness and versatility
