88444-27-3Relevant academic research and scientific papers
1-hydroxy-1,1-bis(H-phosphinates): Synthesis, stability, and sorption properties
David, Tomas,Kreckova, Pavlina,Kotek, Jan,Kubicek, Vojtech,Lukes, Ivan
, p. 195 - 201 (2012)
A synthesis of 1-hydroxy-1,1-bis(H-phosphinates) from acylchlorides is described. Solid-state structures of two bis(phosphinates) determined by X-ray diffraction showed variations in the Pi-C distances. The compounds show negligible sorption on hydroxyapatite and an intermediate chemical stability in aqueous solution. The hydrolysis occurs in acidic as well as alkaline media. Hydrolysis rates of four derivatives show the lowest stability for aromatic derivatives as a result of the electron-withdrawing effect. Main products of hydrolysis are 1-hydroxy-(H-phosphinates) and phosphorous acid.
Three component Kabachnik-Fields condensation leading to substituted aminomethane-P-hydroxymethylphosphonic acids as atool for screening of bacterial urease inhibitors
Vassiliou, Stamatia,Grabowiecka, Agnieszka,Kosikowska, Paulina,Berlicki, Lukasz
experimental part, p. 33 - 43 (2012/03/08)
Condensation of hydroxyalkane-H-phosphinic acids, formaldehyde and secondary amines has given entry to the synthesis of variously substituted aminomethane-P-hydroxymethylphosphinic acids. The proposed strategy allowed to perform a feasible synthesis of several molecules with designed biological activity towards bacterial urease - an enzyme which is a medicinally relevant molecular target. The inhibitory potency of compounds was validated using enzyme purified from Bacillus pasteurii. ARKAT-USA, Inc.
