88446-87-1 Usage
Type of compound
Amino acid derivative and steroid hormone.
Core structure
Cyclopenta[a]phenanthrene.
Configuration
4R at the 4-position, 3R, 5S, 7S, 10R, 13R, 17R at the other positions.
Hydrocarbon skeleton
Tetradecahydro (14-carbon) structure.
Hydroxyl groups
Two hydroxyl groups at the 3and 7-positions.
Methyl groups
Two methyl groups at the 10and 13-positions.
Side chains
A pentanoyl group and a methyl-amino group.
Amino acid residue
Derived from hydroxymethylpropionic acid.
Biological activity
Potential binding to specific receptors in the body due to structural resemblance to steroid hormones.
Pharmaceutical applications
Potential therapeutic uses, but requires further research and experimentation to determine precise biological effects.
Check Digit Verification of cas no
The CAS Registry Mumber 88446-87-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,4,4 and 6 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88446-87:
(7*8)+(6*8)+(5*4)+(4*4)+(3*6)+(2*8)+(1*7)=181
181 % 10 = 1
So 88446-87-1 is a valid CAS Registry Number.
InChI:InChI=1/C27H45NO5/c1-16(5-8-23(31)28(4)15-24(32)33)19-6-7-20-25-21(10-12-27(19,20)3)26(2)11-9-18(29)13-17(26)14-22(25)30/h16-22,25,29-30H,5-15H2,1-4H3,(H,32,33)/t16-,17+,18-,19-,20?,21?,22+,25?,26+,27-/m1/s1
88446-87-1Relevant academic research and scientific papers
Kimura,Hatono,Une,Fukuoka,Kuramoto,Hoshita
, p. 677 - 687 (1984)
Sarcosine conjugated ursodeoxycholic acid (SUDC) was synthesized and its intestinal absorption and metabolism were studied in rat and hamster. Intestinal absorption study using bile fistula rat shows that more than 90% of SUDC administered intraduodenally was excreted in the bile within 24 hr. No change of the administered bile acid was seen during the absorption from the intestine, the passage of the liver, and the excretion into the bile. When [24-14C]SUDC and [11,12-3H2]-ursodeoxycholic acid were administered orally to a hamster, more than 95% of both the administered 14C and 3H were recovered from the feces within 6 days. Most (77%) of the fecal 14C-labeled compound was SUDC, whereas 95% of the fecal 3H-labeled compound was unconjugated lithocholic acid. These results indicate that SUDC, unlike taurine or glycine conjugated bile acid, resists bacterial deconjugation and 7-dehydroxylation.
