884482-60-4Relevant academic research and scientific papers
Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases
Macías, Benigno,Villa, María V.,Salgado, Mónica,Borrás, Joaquín,González-álvarez, Marta,Sanz, Francisca
, p. 1465 - 1472 (2006)
Reaction between 2-picolylamine (2-aminomethylpyridine) with 2-mesitylenesulfonyl and 4-tert-butylbenzene sulfonyl chlorides leads to the formation of 2,4,6-trimethyl-N-[pyridin-2-ilmethyl]benzenesulfonamide (Hpmesa) and 4-ter-butyl-N-[pyridin-2-ilmethyl]benzenesulfonamide (Hptbsa). These compounds react with Cu(II) salts to yield coordination compounds with CuL 2 stoichiometry. The immediate environment of the metal ion is a highly distorted tetrahedron, the sulfonamide ligands acting in a bidentate fashion. Compound Hpmesa crystallizes in monoclinic space group P21/c (number 14), with Z = 4; complex [Cu(pmesa)2] crystallizes in monoclinic space group P1? (number 2), with Z = 4 and complex [Cu(ptbsa)2] crystallizes in monoclinic space group Pca21 (number 29), with Z = 4. Both complexes have been characterized by spectroscopic methods. EPR measurements show rhombic spectra with parameters indicating that the unpaired electron is in dx2-y2 orbital. The two complexes act as chemical nucleases in the presence of ascorbate/H2O2, the reactive oxygen species being the hydroxyl and the singlet oxygen-like species.
