884489-18-3Relevant academic research and scientific papers
Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials
Haemers, Timothy,Wiesner, Jochen,Busson, Roger,Jomaa, Hassan,Van Calenbergh, Serge
, p. 3856 - 3863 (2006)
Fosmidomycin represents a new antimalarial drug that acts by inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an essential enzyme of the mevalonate-independent pathway of isoprenoid biosynthesis. This work describes the synthesis of a series
ORGANOPHOSPHORIC DERIVATIVES USEFUL AS ANTI-PARASITIC AGENTS
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Page/Page column 28-29, (2008/06/13)
The present invention relates to novel phosphonic acid compounds having the structural formula (I): wherein: (a) R is a group of 1 to 5 substituents independently selected from the group consisting of fluoro, chloro, bromo, C1-4 alkoxy, C1
Synthesis of α-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors
Haemers, Timothy,Wiesner, Jochen,Van Poecke, Sara,Goeman, Jan,Henschker, Dajana,Beck, Edwald,Jomaa, Hassan,Van Calenbergh, Serge
, p. 1888 - 1891 (2007/10/03)
In view of the promising antimalarial activity of fosmidomycin or its N-acetyl homologue FR900098, the objective of this work was to investigate the influence of aromatic substituents in the α-position of the phosphonate moiety. The envisaged analogues we
