884489-26-3Relevant academic research and scientific papers
Synthesis of α-aryl-substituted and conformationally restricted fosmidomycin analogues as promising antimalarials
Haemers, Timothy,Wiesner, Jochen,Busson, Roger,Jomaa, Hassan,Van Calenbergh, Serge
, p. 3856 - 3863 (2007/10/03)
Fosmidomycin represents a new antimalarial drug that acts by inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase, an essential enzyme of the mevalonate-independent pathway of isoprenoid biosynthesis. This work describes the synthesis of a series
