884494-81-9

Usage

Uses

Used in Pharmaceutical Synthesis:
3-Bromo-5-fluoro-2-methoxypyridine is used as a key intermediate in the synthesis of 5-Fluoro-2-methoxy-3-(2R)-2-pyrrolidinylpyridine (1213093-30-1), a compound with potential therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and selectivity, contributing to advancements in medicinal chemistry and drug discovery.

InChI:InChI=1/C6H5BrFNO/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,1H3

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 51173-04-7 5-fluoro-2-methoxypyridine 
• 884494-94-4 3-bromo-5-fluoropyridin-2(1H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 943153-49-9 [4-(5-fluoro-2-methoxy-pyridin-3-yl)-benzyl]-carbamic acid-tert-butyl ester 
• 1260845-81-5 C₁₀H₁₃FN₂O*2ClH 
• 122433-52-7 5-fluoro-2-methoxynicotinic acid methyl ester 
• 351410-62-3 5-fluoro-2-methoxypyridine-3-carbaldehyde 
• 884494-82-0 5-fluoro-2-methoxy-pyridine-3-carboxylic acid 
• 874822-98-7 (5-fluoro-2-methoxypyridin- 3-yl)methanol 
• 957120-32-0 (5-fluoro-2-methoxypyridin-3-yl)boronic acid 
• 1093951-75-7 3-bromo-2,5-dimethoxypyridine 
• 1083168-95-9 5-fluoro-2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 943153-14-8 1-[4-(5-fluoro-2-methoxy-pyridin-3-yl)-phenyl]-ethanone 

Relevant academic research and scientific papers

Synthesis process of 2-methoxy-3-bromo-5-fluoropyridine

The invention discloses a synthesis process of 2-methoxy-3-bromo-5-fluoropyridine, which comprises the following steps: dissolving 2-methoxy-5-aminopyridine in an acid, adding nitrous acid or nitriteto prepare a diazotized intermediate state, reacting with a fluorinating reagent to obtain 2-methoxy-5-fluoropyridine, and carrying out a bromination reaction process on 2-methoxy-5-fluoropyridine anda bromination reagent to obtain 2-methoxy-3-bromo-5-fluoropyridine. The synthesis process provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, high yield, easiness in industrial production and the like.

SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS

Compounds of Formula (I) and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.