884494-81-9

Basic information

• Product Name: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE
• Synonyms: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE;3-Bromo-5-fluoro-2-methoxypyridine ,98%;Pyridine, 3-bromo-5-fluoro-2-methoxy-;3-Bromo-5-fluoropyridin-2-yl methyl ether
• CAS NO: 884494-81-9
• Molecular Formula: C₆H₅BrFNO
• Molecular Weight: 206.01
• Product Categories: Organohalides;Pyridine;Pyridine Series;Fluorine series
• Mol File: 884494-81-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 188.356 °C at 760 mmHg
• Flash Point: 67.715 °C
• Appearance: /Liquid
• Density: 1.621 g/cm³
• Vapor Pressure: 0.83mmHg at 25°C
• Refractive Index: 1.5390 to 1.5430
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.38±0.20(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE(884494-81-9)
• EPA Substance Registry System: 3-BROMO-5-FLUORO-2-METHOXYPYRIDINE(884494-81-9)

Safety Data

• Hazardous Substances Data: 884494-81-9(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-fluoro-2-methoxypyridine is a compound used in the synthesis of 5-Fluoro-2-methoxy-3-(2R)-2-pyrrolidinylpyridine (1213093-30-1).

InChI:InChI=1/C6H5BrFNO/c1-10-6-5(7)2-4(8)3-9-6/h2-3H,1H3

Upstream product

• 4548-45-2 2-chloro-5-nitropyridine 
• 5446-92-4 2-methoxy-5-nitropyridine 
• 51173-04-7 5-fluoro-2-methoxypyridine 
• 884494-94-4 3-bromo-5-fluoropyridin-2(1H)-one 
• 74-88-4 methyl iodide 

Downstream Products

• 1260845-81-5 C₁₀H₁₃FN₂O*2ClH 
• 122433-52-7 5-fluoro-2-methoxynicotinic acid methyl ester 
• 351410-62-3 5-fluoro-2-methoxypyridine-3-carbaldehyde 
• 884494-82-0 5-fluoro-2-methoxy-pyridine-3-carboxylic acid 
• 874822-98-7 (5-fluoro-2-methoxypyridin- 3-yl)methanol 
• 957120-32-0 (5-fluoro-2-methoxypyridin-3-yl)boronic acid 
• 1093951-75-7 3-bromo-2,5-dimethoxypyridine 
• 1083168-95-9 5-fluoro-2-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine 
• 943153-49-9 [4-(5-fluoro-2-methoxy-pyridin-3-yl)-benzyl]-carbamic acid-tert-butyl ester 
• 943153-14-8 1-[4-(5-fluoro-2-methoxy-pyridin-3-yl)-phenyl]-ethanone 

Relevant articles and documents

Synthesis process of 2-methoxy-3-bromo-5-fluoropyridine

The invention discloses a synthesis process of 2-methoxy-3-bromo-5-fluoropyridine, which comprises the following steps: dissolving 2-methoxy-5-aminopyridine in an acid, adding nitrous acid or nitriteto prepare a diazotized intermediate state, reacting with a fluorinating reagent to obtain 2-methoxy-5-fluoropyridine, and carrying out a bromination reaction process on 2-methoxy-5-fluoropyridine anda bromination reagent to obtain 2-methoxy-3-bromo-5-fluoropyridine. The synthesis process provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, high yield, easiness in industrial production and the like.