884627-98-9Relevant articles and documents
Synthesis of Tetrahydroquinoline-Embedded Bridged Benzothiaoxazepine-1,1-dioxides
Borgohain, Hemi,Devi, Runjun,Dheer, Divya,Borah, Biraj Jyoti,Shankar, Ravi,Das, Sajal Kumar
, p. 6671 - 6679 (2017)
A diastereoselective synthesis of previously unknown tetrahydroquinoline-containing bridged benzothiaoxazepine-1,1-dioxides is presented. The three-step protocol uses readily available N-aryl-2-fluorobenzenesulfonamides and trans-2,3-epoxy-cinnamyl-alcohol-derived tosylates as the starting materials, involves N-alkylation of sulfonamides, intramolecular epoxide ring-opening, and SNAr reactions as the reaction steps, and requires only one chromatographic purification to access the desired products in good overall yields.