884627-98-9Relevant academic research and scientific papers
Synthesis of Tetrahydroquinoline-Embedded Bridged Benzothiaoxazepine-1,1-dioxides
Borgohain, Hemi,Devi, Runjun,Dheer, Divya,Borah, Biraj Jyoti,Shankar, Ravi,Das, Sajal Kumar
, p. 6671 - 6679 (2017)
A diastereoselective synthesis of previously unknown tetrahydroquinoline-containing bridged benzothiaoxazepine-1,1-dioxides is presented. The three-step protocol uses readily available N-aryl-2-fluorobenzenesulfonamides and trans-2,3-epoxy-cinnamyl-alcohol-derived tosylates as the starting materials, involves N-alkylation of sulfonamides, intramolecular epoxide ring-opening, and SNAr reactions as the reaction steps, and requires only one chromatographic purification to access the desired products in good overall yields.
NOVEL CERCOSPORAMIDE DERIVATIVE
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Page/Page column 144, (2008/06/13)
The present invention relates to a novel cercosporamide derivative, a pharmacologically acceptable salt thereof or an ester thereof which has an excellent hypoglycemic effect and is useful as a therapeutic and/or prophylactic agent for diabetes. A cercosporamide derivative having the general formula (I): [wherein X represents an oxygen atom or the like, R1 represents a hydrogen atom or a C1-C6 alkyl group, R2 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 halogenated alkyl group, R3 represents a hydrogen atom or a C1-C6 alkyl group, R4 represents a C6-C10 aryl group which may be substituted with one to five group(s) independently selected from Substituent Group a, or the like, n represents 1, 2 or 3, and Substituent Group a represents a halogen atom, a C1-C6 alkyl group, a C1-C6 halogenated alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 alkoxy group, a C1-C6 halogenated alkoxy group, a C2-C6 alkenyloxy group, a C2-C6 alkynyloxy group and the like], a pharmacologically acceptable salt thereof or an ester thereof.
