Cas 884656-80-8,4-Chloro-6-m-tolyl-pyrimidine

884656-80-8

Post Buying Request

Basic information

Product Name: 4-Chloro-6-m-tolyl-pyrimidine
Synonyms: 4-Chloro-6-m-tolyl-pyrimidine
CAS NO:884656-80-8
Molecular Formula: C₁₁H₉ClN₂
Molecular Weight: 204.65556
EINECS: N/A
Product Categories: N/A
Mol File: 884656-80-8.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 4-Chloro-6-m-tolyl-pyrimidine(CAS DataBase Reference)
NIST Chemistry Reference: 4-Chloro-6-m-tolyl-pyrimidine(884656-80-8)
EPA Substance Registry System: 4-Chloro-6-m-tolyl-pyrimidine(884656-80-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 884656-80-8(Hazardous Substances Data)

Suppliers
Usage
Upstream product
Downstream Products
Article

884656-80-8 Suppliers

Recommended suppliers

884656-80-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 884656-80-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,4,6,5 and 6 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 884656-80:
(8*8)+(7*8)+(6*4)+(5*6)+(4*5)+(3*6)+(2*8)+(1*0)=228
228 % 10 = 8
So 884656-80-8 is a valid CAS Registry Number.

884656-80-8Upstream product

884656-80-8Downstream Products

884656-80-8Relevant academic research and scientific papers

Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntingtons disease

Toledo-Sherman, Leticia M.,Prime, Michael E.,Mrzljak, Ladislav,Beconi, Maria G.,Beresford, Alan,Brookfield, Frederick A.,Brown, Christopher J.,Cardaun, Isabell,Courtney, Stephen M.,Dijkman, Ulrike,Hamelin-Flegg, Estelle,Johnson, Peter D.,Kempf, Valerie,Lyons, Kathy,Matthews, Kimberly,Mitchell, William L.,Oconnell, Catherine,Pena, Paula,Powell, Kendall,Rassoulpour, Arash,Reed, Laura,Reindl, Wolfgang,Selvaratnam, Suganathan,Friley, Weslyn Ward,Weddell, Derek A.,Went, Naomi E.,Wheelan, Patricia,Winkler, Christin,Winkler, Dirk,Wityak, John,Yarnold, Christopher J.,Yates, Dawn,Munoz-Sanjuan, Ignacio,Dominguez, Celia

, p. 1159 - 1183 (2015/03/04)

We report on the development of a series of pyrimidine carboxylic acids that are potent and selective inhibitors of kynurenine monooxygenase and competitive for kynurenine. We describe the SAR for this novel series and report on their inhibition of KMO activity in biochemical and cellular assays and their selectivity against other kynurenine pathway enzymes. We describe the optimization process that led to the identification of a program lead compound with a suitable ADME/PK profile for therapeutic development. We demonstrate that systemic inhibition of KMO in vivo with this lead compound provides pharmacodynamic evidence for modulation of kynurenine pathway metabolites both in the periphery and in the central nervous system.

COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE

-

Page/Page column 90, (2008/06/13)

The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 884656-80-8