88466-76-6

Usage

Uses

Used in Pharmaceutical Industry:
(S)-N-Boc-piperidine-3-carboxylate methyl ester is used as a key intermediate for the development of new drugs. Its ability to efficiently introduce the piperidine ring into more complex molecules makes it a valuable building block in the synthesis of various pharmaceutical compounds.
Used in Organic Synthesis:
(S)-N-Boc-piperidine-3-carboxylate methyl ester is used as a versatile intermediate for the synthesis of a wide range of organic compounds. The N-Boc protecting group allows for selective reactions to occur, while the methyl ester group provides a convenient point of attachment for further functionalization.

Upstream product

• 88495-54-9 (3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid 
• 74-88-4 methyl iodide 
• 534572-20-8 (3S,5R)-1-(tert-butoxycarbonyl)-3-(methoxycarbonyl)piperidine-5-carboxylic acid 
• 157226-76-1 1-tert-butyl 3,5-dimethyl piperidine-1,3,5-tricarboxylate 
• 499-81-0 3,5-Pyridinedicarboxylic acid 

Downstream Products

• 276248-50-1 (S)-methyl piperidine-3-carboxylate 
• 140695-84-7 tert-butyl (3S)-3-(hydroxymethyl)piperidine-1-carboxylate 

Relevant academic research and scientific papers

HETEROARYLAMIDE LOWER CARBOXYLIC ACID DERIVATIVE

To provide a novel compound which has S1P receptor agonistic activity, exhibits excellent immunosuppressing effect, gives less adverse side effects, and can be orally administered. The invention provides a compound represented by general formula (I) (wherein A is a single bond, -O-, or - CH2-; R1 represents a hydrogen atom or a C1-C6 alkyl group, and V represents any one group selected from among the following groups (1) to (3) : (1) -G1-, (2) -G2-N(R2) -G3-, and (3) a group represented by formula 2, wherein each of Z1 and Z2 represents a hydrogen atom or a C1-C6 alkyl group, Z3 represents a hydrogen or the like, Q represents -CH2-O- or the like, and Y represents a group represented by foumula 3, a salt thereof, or a solvate thereof.

An efficient synthesis of 3(S)-aminopiperidine-5(R)-carboxylic acid as a cyclic β,γ′-diamino acid

An orthogonally protected β,γ′-diamino acid 6 possessing conformationally-constrained ring system was synthesized as a novel cyclic amino acid analogue. This synthesis involves as key steps chemoselective enzymatic hydrolysis of cis-piperidine-3,5-dicarboxylic ester derivative followed by efficient kinetic resolution of the partially resolved half-acid to afford the C1-symmetric piperidine-3,5-dicarboxylic acid monoester in high enantiomeric excess (>98% ee). The optically active half-acid was transformed to the cyclic amino acid via Curtius-type rearrangement.