88474-01-5Relevant academic research and scientific papers
Enantioselective syntheses of candenatenins B and C using a chiral anthracene auxiliary
Jones, Amanda L.,Liu, Xiang,Snyder, John K.
scheme or table, p. 1091 - 1094 (2010/04/05)
The asymmetric syntheses of two anticancer natural products, candenatenins B and C, are described, leading to a revision of the originally assigned stereochemistries. The syntheses follow a Diels-Alder/retro-Diels Alder strategy using a chiral anthracene auxiliary to access both targets with 90% ee. The inherent structural qualities of the auxiliary allow for both regio- and diastereoselective transformations.
