88476-50-0Relevant academic research and scientific papers
Activated carbon as the reagent for the oxidative cyclization of fullerene adducts
Bernstein, Robert,Foote, Christopher S.
, p. 7051 - 7054 (1998)
Reaction of C60 with diethylaminopropyne leads to cyclobutene adduct 1, which upon acid hydrolysis provides a facile synthetic route to fullerene adduct 2. Subsequent oxidative cyclization involving activated carbon yields the novel fullerene lactone 3.
Quinoline or quinazoline derivatives, its preparation process and its use in medicine
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Paragraph 0263; 0267-0269, (2018/01/19)
The invention relates to a quinoline or quinazoline derivative, its preparation method and an application in medicines, specifically to new quinoline or quinazoline derivative as shown in a general formula (I) and its medicinal salt or a pharmaceutical composition containing the derivative and a preparation method thereof. The invention further relates to an application of the quinoline or quinazoline derivative and its medicinal salt or the pharmaceutical composition containing the derivative in the preparation of a therapeutic agent, especially a protein kinase inhibitor. Each substituent group in the general formula (I) has the same definition as in the specification.
TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY, SUBSTITUTED IN POSITION 3 BY A NON-AROMATIC RING CARRYING A HALOALKYL SUBSTITUENT
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Page/Page column 188; 189, (2015/11/03)
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formula I: with X selected from C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6 cyclodialkenyl, C6 oxacyclodialkenyl, C6-9 oxaspirocycloalkyl and C6-9 oxaspirocycloalkenyl ring, such that X is substituted with A, wherein A is -C1-6 alkyl- halo. These compounds are useful for the treatment of HIV and AIDS.
Acid-Stable, Solvolytically Deblocked Amino-Protecting-Groups Applications of the 1,3-Dibromo-2-methyl-2-propyloxycarbonyl (DB-t-Boc) Group
Carpino, Louis A.,Rice, Norman W.,Mansour, E. M. E.,Triolo, Salvatore A.
, p. 836 - 842 (2007/10/02)
The effects of structure on the ease of solvolytic deblocking of an array of α-halo-tert-alkyl carbamates 1 have been studied.The corresponding thiolcarbamates were shown to undergo isomerization and other reactions due to participation of the sulfur atom
