884869-15-2Relevant academic research and scientific papers
Synthesis of (+)-Sch 642305 by a biomimetic transannular Michael reaction
Snider, Barry B.,Zhou, Jingye
, p. 1283 - 1286 (2006)
The synthesis of (+)-Sch 642305 (1) has been completed in 17 steps in 1.6% overall yield. Transannular Michael reaction of 2b with NaH in THF provided cyclohexenone 23 stereospecifically. Heating 23 in TFA/CDCI3 provided a 3:1 equilibrium mixture of 23 and 25, which was hydrolyzed to give (+)-6-epi-Sch 642305 (24) and (+)-Sch 642305 (1), respectively.
