884877-06-9Relevant academic research and scientific papers
Transformation of 5-hydroxy- to (5-chloropentanoyl)amino derivatives under 'direct amide cyclization' conditions
Iliev, Boyan,Verma, Sanjiv,Linden, Anthony,Heimgartner, Heinz
, p. 352 - 359 (2007/10/03)
The application of the 'direct amide cyclization' conditions to the linear δ-hydroxy diamide 11 is described (Scheme 3). Instead of the cyclization to the expected nine-membered cyclodepsipeptide, only the chloro acid 12 was obtained. Its formation could
