88498-46-8 Usage
Description
Hypoestoxide, derived from Hypoestes rosea, is a naturally occurring, cell-permeable diterpene. It is a selective and direct IKK (IκB kinase) inhibitor in TNF-α stimulated HeLa cells, preventing NF-κB activation. Additionally, Hypoestoxide inhibits nitric oxide production by IL-1β or IL-17 stimulated chondrocytes.
Uses
Used in Pharmaceutical Industry:
Hypoestoxide is used as an IKK inhibitor for its ability to prevent NF-κB activation in TNF-α stimulated HeLa cells, making it a potential candidate for the development of anti-inflammatory and immunomodulatory drugs.
Used in Cartilage Protection:
Hypoestoxide is used as a chondrocyte protector for its ability to inhibit nitric oxide production in IL-1β or IL-17 stimulated chondrocytes, which may help in the treatment and prevention of cartilage degradation in conditions such as osteoarthritis.
Check Digit Verification of cas no
The CAS Registry Mumber 88498-46-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,4,9 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 88498-46:
(7*8)+(6*8)+(5*4)+(4*9)+(3*8)+(2*4)+(1*6)=198
198 % 10 = 8
So 88498-46-8 is a valid CAS Registry Number.