885013-14-9Relevant academic research and scientific papers
The synthesis of sutezolid and eperezolid using proline catalyzed α-aminoxylation of an aldehyde
Bhat, Varadaraj,Bhise, Nandu B,Chaudhari, Pankaj R,Shenoy, Gautham G,Singh, Girij P
, (2022/04/25)
The given article describes the synthesis of 2-Oxazolidinone ring via proline catalyzed stereoselective α-aminoxylation of aldehyde. 2-Oxazolidinone ring is a common core structure during the synthesis of oxazolidinones class molecules. Using this simple, facile and efficient methodology, Linezolid and sutezolid were prepared using asymmetric catalysis. Graphical abstract: Selective α-aminoxylation was achieved on corresponding aldehyde with great enantiomeric excess to get intermediate (5) using catalytic amount of low cost proline. The oxazolidinone ring was then constructed on common intermediate (5) which was then further converted to Oxazolidinone class compounds like Sutezolid and Eperezolid.[Figure not available: see fulltext.].
OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS
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Page/Page column 31, (2010/11/08)
The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiple-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacterioides spp. and Clostridia spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
