885032-77-9Relevant academic research and scientific papers
Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918
Paone, Daniel V.,Nguyen, Diem N.,Shaw, Anthony W.,Burgey, Christopher S.,Potteiger, Craig M.,Deng, James Z.,Mosser, Scott D.,Salvatore, Christopher A.,Yu, Sean,Roller, Shane,Kane, Stefanie A.,Selnick, Harold G.,Vacca, Joseph P.,Williams, Theresa M.
scheme or table, p. 2683 - 2686 (2011/06/20)
In our ongoing efforts to develop CGRP receptor antagonists for the treatment of migraine, we aimed to improve upon telecagepant by targeting a compound with a lower projected clinical dose. Imidazoazepanes were identified as potent caprolactam replacemen
