885058-67-3Relevant academic research and scientific papers
An alternative synthesis of the dopaminergic drug 2-amino-1,2,3,4- tetrahydronaphthalene-5,6-diol (5,6-ADTN)
Goeksu, Sueleyman,Secen, Hasan,Suetbeyaz, Yasar
, p. 270 - 273 (2006)
Racemic 2-amino-1,2,3,4-tetrahydronaphthalene-5,6-diol (5,6-ADTN; 4) was synthesized from 5,6-dimethoxynaphthalene-2-carboxylic acid (14) in four steps (60% overall yield; Scheme). The crucial steps of the synthesis are Birch reduction of 14 to the valuable synthon 15, Curtius reaction and carbamate formation (16), hydrogenolysis (17), and demethylation to the biologically active hydrobromide salt 18 of 4.
