885104-48-3

Upstream product

• 119461-40-4 S-(+)-2-methyl-N-p-tosylaziridine 
• 1066-54-2 trimethylsilylacetylene 
• 119461-41-5 (S)-N-(p-toluenesulfonyl)-4-amino-1-(trimethylsilyl)-1-pentyne 

Relevant academic research and scientific papers

TMSOTf mediated '5/6-: Endo-dig ' reductive hydroamination for the stereoselective synthesis of pyrrolidine and piperidine derivatives

A TMSOTf mediated 5/6-endo-dig reductive hydroamination cascade on internal alkynylamines gave expedient, stereoselective access to pyrrolidine and piperidine derivatives. We also demonstrate that a protecting group on nitrogen has a profound effect on the reactivity as well as diastereoselectivity of the reductive hydroamination cascade.

NOVEL B1 BRADYKININ RECEPTOR ANTAGONISTS

The invention encompasses novel compounds of a formula I and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for treatment of diseases mediated by B1 bradykinin receptor.