885107-69-7

Upstream product

• 864498-74-8 (S)-6-allyltetrahydro-2H-pyran-2-one 
• 123-73-9 crotonaldehyde 
• 480453-25-6 ((1-(benzyloxy)-2-methylprop-1-en-1-yl)oxy)trimethylsilane 
• 1325653-83-5 benzyl 2-((2R,6S)-6-(cyanomethyl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 1325653-45-9 benzyl 2-((2R,6S)-6-(((mesitylsulfonyl)oxy)methyl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 1325653-82-4 C₁₉H₂₈O₆S 
• 1325653-43-7 ((2S,6R)-6-(2-methyl-1-oxopropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate 
• 1325653-69-7 (2R,3S)-3-(dimethyl(phenyl)silyl)-2-((trimethylsilyl)oxy)pent-4-en-1-yl 2,4,6-trimethylbenzenesulfonate 
• 1325653-80-2 ((2S,6R)-6-(1-hydroxy-2-methylpropan-2-yl)tetrahydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate 
• 1325653-42-6 ((2S,6R)-6-(1-(benzyloxy)-2-methylpropan-2-yl)-5,6-dihydro-2H-pyran-2-yl)methyl 2,4,6-trimethylbenzenesulfonate 
• 1350890-03-7 C₂₂H₃₀O₄SSi 
• 1325653-68-6 C₁₃H₂₀O₂Si 
• 864498-75-9 2-((2R,6S)-6-Allyl-tetrahydro-pyran-2-yl)-2-methyl-propionic acid benzyl ester 
• 1027220-23-0 5-hydroxy-oct-7-enoic acid tert-butyl ester 

Downstream Products

• 864498-88-4 benzyl 2-((2R,6S)-6-((R)-2-(benzyloxy)pent-4-en-1-yl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 1325653-33-5 2-(benzyloxy)-6-(3-((2S,6S)-6-((3S,4R,6R)-6-(benzyloxy)-7-((2S,6R)-6-(1-(benzyloxy)-2-methyl-1-oxopropan-2-yl)tetrahydro-2H-pyran-2-yl)-4-hydroxy-3-methylheptyl)tetrahydro-2H-pyran-2-yl)propyl)benzoic acid 
• 1325653-61-9 2-(trimethylsilyl)ethyl 2-(benzyloxy)-6-(3-((2S,6S)-6-((3S,4R,6R)-6-(benzyloxy)-7-((2S,6R)-6-(1-(benzyloxy)-2-methyl-1-oxopropan-2-yl)tetrahydro-2H-pyran-2-yl)-4-hydroxy-3-methylheptyl)tetrahydro-2H-pyran-2-yl)propyl)benzoate 
• 1325653-58-4 2-(trimethylsilyl)ethyl 2-(benzyloxy)-6-(3-((2S,6S)-6-((3S,4R,6S)-6-(benzyloxy)-7-((2S,6R)-6-(1-(benzyloxy)-2-methyl-1-oxopropan-2-yl)tetrahydro-2H-pyran-2-yl)-4-((tert-butyldimethylsilyl)oxy)-3-methylheptyl)tetrahydro-2H-pyran-2-yl)propyl)benzoate 
• 1325653-89-1 2-(trimethylsilyl)ethyl 2-(benzyloxy)-6-(3-((2S,6S)-6-((3S,4R,6S,E)-6-(benzyloxy)-7-((2S,6R)-6-(1-(benzyloxy)-2-methyl-1-oxopropan-2-yl)tetrahydro-2H-pyran-2-yl)-4-((tert-butyldimethylsilyl)oxy)-3-methylhept-1-en-1-yl)tetrahydro-2H-pyran-2-yl)propyl)benzoate 
• 1325653-88-0 benzyl 2-((2R,6S)-6-((2S,4R,5S,6E)-2-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)-7-((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)tetrahydro-2H-pyran-2-yl)-5-methylhept-6-en-1-yl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 1325653-37-9 benzyl 2-((2R,6S)-6-((2S,4R,5S)-2-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)-5-methylhept-6-en-1-yl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 864498-72-6 benzyl 2-((2R,6S)-6-((2S,4R,5S)-2-(benzyloxy)-4-((tert-butyldimethylsilyl)oxy)-7-((2S,6S)-6-(3-(2,2-dimethyl-4-oxo-4H-benzo[d][1,3]dioxin-5-yl)propyl)tetrahydro-2H-pyran-2-yl)-5-methylheptyl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 
• 864498-77-1 benzyl 2-((2R,6S)-6-((S)-2-(benzyloxy)-4-oxobutyl)tetrahydro-2H-pyran-2-yl)-2-methylpropanoate 

Relevant academic research and scientific papers

Total Synthesis of (+)-SCH 351448: Efficiency via Chemoselectivity and Redox-Economy Powered by Metal Catalysis

The polyketide natural product (+)-SCH 351448, a macrodiolide ionophore bearing 14 stereogenic centers, is prepared in 14 steps (LLS). In eight prior syntheses, 22-32 steps were required. Multiple chemoselective and redox-economic functional group interco

Total synthesis of (+)-SCH 351448

A convergent synthesis of (+)-SCH 351448 (1), a monosodium salt of a C 2-symmetric macrodiolide, is described. Our approach is based on a [4 + 2] annulation with a chiral allyl silane (anti-5c) to assemble the pyran subunits. Homodimerization w

Efficient asymmetric synthesis of (+)-SCH 351448

(Chemical Equation Presented) An efficient and stereocontrolled total synthesis of (+)-SCH 351448, a novel activator of low-density lipoprotein receptor promoter, has been achieved with a longest linear sequence of 21 steps. Key steps include applications