885125-88-2

Upstream product

• 885125-87-1 [5-(allyloxycarbonylamino)-6-{5-[4-(3,4-dichlorophenethyloxy)phenylmethyl]-[1,2,4]oxadiazol-3-yl}-6-(tert-butyl-dimethylsilyloxy)-hexyl]-carbamic acid tert-butyl ester 
• 900515-82-4 [5-(allyloxycarbonylamino)-5-(N-methoxy-N-methyl-carbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 885125-85-9 [5-(allyloxycarbonylamino)-6-cyano-6-(tert-butyl-dimethylsilyloxy)-hexyl]-carbamic acid tert-butyl ester 
• 2389-60-8 Z-Lys(Boc)-OH 
• 172833-41-9 benzyl tert-butyl (6-(methoxy(methyl)amino)-6-oxohexane-1,5-diyl)(S)-dicarbamate 
• 188947-18-4 [5-(allyloxycarbonylamino)-6-oxo-hexyl]-carbamic acid tert-butyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 900515-79-9 C₃₈H₅₆Cl₂N₄O₈Si 
• 885125-86-0 [5-allyloxycarbonylamino-6-(tert-butyl-dimethyl-silanyloxy)-6-(N-hydroxycarbamimidoyl)-hexyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors

Using a scaleable, directed library approach based on orthogonally protected advanced intermediates, we have prepared a series of potent keto-1,2,4-oxadiazoles designed to explore the P2 binding pocket of human mast cell tryptase, while buildin

ACTIVE KETONE INHIBITORS OF TRYPTASE

The present invention related to certain active tetracyclic ketone inhibitors of tryptase, pharmaceutical composition comprising these compounds and methods of treating asthma, allergic rhinitis, and/or Chronic Obstructive Pulmonary Disease utilizing thes