88519-57-7 Usage
Uses
Used in Scientific Research:
N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride is used as a calmodulin antagonist for inhibiting calcium-ion-calmodulin-regulated activities. It binds to calmodulin and inhibits the activation of phosphodiesterase and myosin light chain kinase, making it a valuable tool for studying the role of calmodulin in various biological processes.
Used in Pharmaceutical Development:
As a calmodulin antagonist, N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride may have potential applications in the development of drugs targeting calmodulin-regulated pathways. This could lead to the discovery of new therapeutic agents for treating diseases associated with abnormal calmodulin activity.
Used in Drug Delivery Systems:
N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride can be incorporated into drug delivery systems to improve the targeted delivery of calmodulin antagonists to specific tissues or cells. This may enhance the therapeutic efficacy and reduce side effects associated with the use of calmodulin inhibitors.
Used in Diagnostic Applications:
The ability of N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide hydrochloride to bind and inhibit calmodulin activity can be utilized in diagnostic assays to assess calmodulin function and its role in various diseases. This may aid in the development of diagnostic tools for calmodulin-related disorders.
Biological Activity
Calmodulin antagonist (inhibits calmodulin activated PDE activity with an IC 50 of 68 μ M). Inhibits growth of tamoxifen-resistant breast cancer cells.
Biochem/physiol Actions
W-13 has also been shown to inhibit the transcytosis of IgA, recycling of transferrin and overall alter the endocytic pathway in Madin-Darby canine kidney cells.
Check Digit Verification of cas no
The CAS Registry Mumber 88519-57-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,8,5,1 and 9 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 88519-57:
(7*8)+(6*8)+(5*5)+(4*1)+(3*9)+(2*5)+(1*7)=177
177 % 10 = 7
So 88519-57-7 is a valid CAS Registry Number.
InChI:InChI=1/C14H17ClN2O2S.ClH/c15-14-5-3-4-11-10-12(6-7-13(11)14)20(18,19)17-9-2-1-8-16;/h3-7,10,17H,1-2,8-9,16H2;1H
88519-57-7Relevant academic research and scientific papers
Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation
-
, (2008/06/13)
A method of regulating phosphorylation of proteins involved in controlling processing or function of key proteins found in intracellular neurofibrillary tangles and extracellular amyloid plaques associated with Alzheimer disease comprising introducing an effective amount of a kinase modulator or phosphatase modulator, the modulator capable of increasing or decreasing the rate of proteolytic processing, or modulating the function, of said key proteins.
