885222-85-5 Usage
Structure
A derivative of 1,3,4-thiadiazole-2-amine and 1H-indazol-5-yl, both heterocyclic compounds
Chemical classification
Heterocyclic compound
Medicinal chemistry
Potential drug candidate for therapeutic applications
Treatment
Various diseases and conditions
Organic syntheses
Potential applications due to unique structure and properties
Chemical research
Further studies and research needed to understand potential uses and applications
Thiadiazole ring
Five-membered ring with two nitrogen atoms and one sulfur atom
Amine group
Nitrogen atom bonded to one hydrogen atom and a side chain (R group)
Phenyl group
Aromatic ring with six carbon atoms and six hydrogen atoms
Indazole ring
Seven-membered ring with one nitrogen atom and a fused six-membered ring containing a nitrogen atom
Potential for further research
Due to its unique structure and properties, 1,3,4-Thiadiazol-2-amine, 5-(3-phenyl-1H-indazol-5-yl)- may have additional applications in various fields once further studied and understood.
Check Digit Verification of cas no
The CAS Registry Mumber 885222-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,2 and 2 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 885222-85:
(8*8)+(7*8)+(6*5)+(5*2)+(4*2)+(3*2)+(2*8)+(1*5)=195
195 % 10 = 5
So 885222-85-5 is a valid CAS Registry Number.
885222-85-5Relevant academic research and scientific papers
Zeng, Qingping,Bourbeau, Matthew P.,Wohlhieter, G. Erich,Yao, Guomin,Monenschein, Holger,Rider, James T.,Lee, Matthew R.,Zhang, Shiwen,Lofgren, Julie,Freeman, Daniel,Li, Chun,Tominey, Elizabeth,Huang, Xin,Hoffman, Douglas,Yamane, Harvey,Tasker, Andrew S.,Dominguez, Celia,Viswanadhan, Vellarkad N.,Hungate, Randall,Zhang, Xiaoling
, p. 1652 - 1656 (2010)
A series of 2-aminothiadiazole of inhibitors of AKT1 is described. SAR relationships are discussed, along with selectivity for protein kinase A (PKA) and cyclin-dependent kinase 2 (CDK2). Moderate selectivity observed in several compounds for AKT1 versus PKA is rationalized by X-ray crystallographic analysis. Key compounds showed activity in cellular assays measuring phosphorylation of two AKT substrates, PRAS40 and FKHRL1. Compound 30 was advanced to a mouse liver PD assay, where it showed dose-dependent inhibition of AKT activity, as measured by the inhibition of phospho-PRAS40.
