885228-03-5Relevant articles and documents
Hypoxia-activated prodrugs: Substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents
Tercel, Moana,Atwell, Graham J.,Yang, Shangjin,Stevenson, Ralph J.,Botting, K. Jane,Boyd, Maruta,Smith, Eileen,Anderson, Robert F.,Denny, William A.,Wilson, William R.,Pruijn, Frederik B.
, p. 7258 - 7272 (2009)
Nitrochloromethylbenzindolines (nitroCBIs) are a new class of hypoxia-activated prodrugs for antitumor therapy. The recently reported prototypes undergo hypoxia-selective metabolism to form potent DNA minor groove alkylating agents and are selectively tox