88526-59-4

Usage

Uses

Used in Pharmaceutical Research:
2-aminopyridine-4-carbothioamide is used as a building block in organic synthesis for the development of various compounds. Its antitumor and antiviral activity has garnered interest in pharmaceutical research, indicating its potential for use in the creation of therapeutic agents.
Used in Corrosion Inhibition:
2-aminopyridine-4-carbothioamide is used as a corrosion inhibitor for metals. Its application in this field is due to its ability to protect metals from degradation, thereby extending their lifespan and improving their performance.
Used in Coordination Chemistry:
In the field of coordination chemistry, 2-aminopyridine-4-carbothioamide is used as a ligand. Its role in this context is to bind to metal ions, forming stable complexes that can be utilized in various chemical and catalytic processes.

Upstream product

• 13538-42-6 2-amino-isonicotinamide 
• 42182-27-4 4-cyanopyridin-2-amine 

Downstream Products

• 1612886-86-8 ethyl 2-(2-aminopyridin-4-yl)-4-phenylthiazole-5-carboxylate 

Relevant academic research and scientific papers

Heterocyclic Compounds and Methods of Use

This disclosure provides compounds and methods of using those compounds to treat liver fibrosis, including liver fibrosis which is a precursor to, is concurrent with, is associated with, or is secondary to nonalcoholic steatohepatitis (NASH); elevated cholesterol levels, and insulin resistance.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration of the compounds in conjunction with hormone receptor antagonists. Compounds of the invention may also find use in treating cancer. Presented herein are novel compounds bearing a perhaloalkylsulfonamide moiety. Such compounds, in addition to being highly effective SREBP inhibitors, are also unexpectedly highly bioavailable in vivo. Heteroaromatic compounds bearing sulfonamide groups are prone to several ionic states, based on the inherent pKa values.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration of the compounds in conjunction with hormone receptor antagonists.

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.

HETEROARYLS AND THEIR USE AS PI3K INHIBITORS

This invention provides compounds of formula (IA) or (IB): wherein R1, R2, G1 and HY are as described in the specification. The compounds are inhibitors of PI3K and/or mTor and are thus useful for treating proliferative, inflammatory, or cardiovascular disorders.