885271-64-7 Usage
Uses
Used in Pharmaceutical Industry:
5-(TRIFLUOROMETHYL)-1H-INDAZOLE is used as a versatile intermediate for the synthesis of various pharmaceutical compounds due to its ability to participate in multiple chemical reactions and enhance the biological activity of drugs.
Used in Medicinal Chemistry Research:
5-(TRIFLUOROMETHYL)-1H-INDAZOLE is used as a key component in the development of new drugs, leveraging its stability and lipophilic properties to improve drug efficacy and pharmacokinetics.
Used in Drug Design and Optimization:
5-(TRIFLUOROMETHYL)-1H-INDAZOLE is employed as a structural element in drug design, contributing to the optimization of drug candidates by enhancing their lipophilicity, metabolic stability, and overall biological activity.
Used in Drug Delivery Systems:
5-(TRIFLUOROMETHYL)-1H-INDAZOLE can be utilized in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of various pharmaceuticals by enhancing their lipophilic properties and stability.
Used in Toxicity and Safety Evaluation:
5-(TRIFLUOROMETHYL)-1H-INDAZOLE is used in the assessment of safety and toxicity profiles of drug candidates during the drug development process, ensuring that the final pharmaceutical products are safe for human use.
Check Digit Verification of cas no
The CAS Registry Mumber 885271-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,5,2,7 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 885271-64:
(8*8)+(7*8)+(6*5)+(5*2)+(4*7)+(3*1)+(2*6)+(1*4)=207
207 % 10 = 7
So 885271-64-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3N2/c9-8(10,11)6-1-2-7-5(3-6)4-12-13-7/h1-4H,(H,12,13)
885271-64-7Relevant academic research and scientific papers
A novel copper-catalyzed, hydrazine-free synthesis of N-1 unsubstituted 1H-indazoles using stable guanylhydrazone salts as substrates
Rekowski, Szymon P.,Kroener, Bettina K.,Kathuria, Deepika,Wani, Aabid A.,Chourasiya, Sumit S.,Conrad, Jürgen,Bharatam, Prasad V.,Frey, Wolfgang,Beifuss, Uwe
, (2021/06/12)
A CuI-catalyzed, hydrazine-free transformation of 2-(2-bromoarylidene)guanylhydrazone hydrochlorides using Cs2CO3 as a base and DMEDA as a ligand at 120 °C for 5 h delivers substituted 1H-indazoles with yields up to 75%. The C,N double bond configuration of the substrates was determined by NMR experiments and quantum chemical calculations. The reaction mechanism was studied using quantum chemical calculations.
Facile synthesis of 3-trimethylsilylindazoles by [3+2]cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes
Shoji, Yoshimichi,Hari, Yoshiyuki,Aoyama, Toyohiko
, p. 1769 - 1771 (2007/10/03)
[3+2]Cycloaddition reaction of lithium trimethylsilyldiazomethane with benzynes, generated from halobenzenes, gave the corresponding 3-trimethylsilylindazoles in good to moderate yields.
